RT Journal Article
SR Electronic
T1 Clinical Significance of Residual Lymph Node Metastasis in Predicting Recurrence After Preoperative Chemotherapy and Surgery for Gastric Cancer
JF Anticancer Research
JO Anticancer Res
FD International Institute of Anticancer Research
SP 1205
OP 1214
DO 10.21873/anticanres.17507
VO 45
IS 3
A1 KOMORI, KEISUKE
A1 YAMADA, TAKANOBU
A1 ANDO, SHUJI
A1 NAGASAWA, SHINSUKE
A1 KANEMATSU, KYOHEI
A1 MORITA, JUNYA
A1 TANABE, MIE
A1 NAKAYAMA, YUTA
A1 RINO, YASUSHI
A1 SAITO, AYA
A1 OGATA, TAKASHI
A1 OSHIMA, TAKASHI
YR 2025
UL http://ar.iiarjournals.org/content/45/3/1205.abstract
AB Background/Aim: Neoadjuvant chemotherapy is gaining recognition for its potential to improve survival outcomes, with combined neoadjuvant and adjuvant therapies under investigation. However, the prognostic significance of post-chemotherapy pathological staging (ypStage) on recurrence-free survival (RFS) remains unclear. This study aimed to evaluate the utility of ypStage, ypT, ypN classification, and histological response rate in predicting recurrence after gastrectomy.Patients and Methods: This retrospective study included 125 patients who underwent radical gastrectomy after preoperative chemotherapy at the Kanagawa Cancer Center between January 2007 and November 2019. RFS was analyzed based on ypStage, ypT, ypN classification, and histological response rate, with prognostic factors also assessed.Results: The 5-year RFS rates were 81.6% for ypStage I, 49.0% for ypStage II, and 42.9% for ypStage III. Significant differences were observed between ypStage I and ypStage II (p=0.025) but not between ypStage II and ypStage III (p =0.633). In ypStage II/III cases, the 5-year RFS rate was significantly higher for ypN0/1/2 (55.4%) compared to ypN3 (21.5%) (p=0.003). ypN was selected as an independent predictor for relapse in multivariate analysis.Conclusion: ypStage effectively predicts recurrence in ypStage I cases after preoperative chemotherapy and surgery for gastric cancer. However, prognosis in patients with ypStage II/III is better stratified using the ypN classification, particularly ypN3.