RT Journal Article
SR Electronic
T1 Correlation of Androgen Receptor Status, Neuroendocrine Differentiation and Angiogenesis with Time-to-Biochemical Failure after Radical Prostatectomy in Clinically Localized Prostate Cancer
JF Anticancer Research
JO Anticancer Res
FD International Institute of Anticancer Research
SP 3651
OP 3660
VO 27
IS 5B
A1 KYRIAKOS REVELOS
A1 CONSTANTINA PETRAKI
A1 ANDREAS SCORILAS
A1 STEFANOS STEFANAKIS
A1 DIMITRIOS MALOVROUVAS
A1 NEKTARIOS ALEVIZOPOULOS
A1 GEORGE KANELLIS
A1 ANTONIS HALAPAS
A1 MICHAEL KOUTSILIERIS
YR 2007
UL http://ar.iiarjournals.org/content/27/5B/3651.abstract
AB The aim of this study was to elucidate the prognostic value of the immunohistochemical detection of the androgen receptor (AR) status, the chromogranin A assessment of neuroendocrine differentiation (NED) and the CD34 assessment of microvessel density (MVD) with time-to-biochemical failure among surgically treated patients with clinically localized prostate cancer. Patients and Methods: Surgical specimens from 130 patients with clinically localized prostate cancer, treated with radical prostatectomy, were analyzed by immunohistochemistry on paraffin tissue sections. Full-length follow-up records were available for 94 patients. Results: Biochemical failure was observed in 37% of these patients. A statistically significant inverse relationship was observed between AR status and: (i) seminal vesicle invasion and (ii) surgical margin infiltration. Positive association was also detected between NED and: (i) Gleason's score, (ii) extracapsular extension, (iii) seminal vesicle invasion, (iv) surgical margin infiltration and (v) tumour volume. In addition, MVD was related to: (i) Gleason score, (ii) extracapsular extension, (iii) seminal vesicle invasion, (iv) pelvic lymph node metastasis and (v) tumour volume. Kaplan-Meier survival curves confirmed that Gleason score, extracapsular extension, seminal vesicle invasion, pelvic lymph node metastasis, tumour volume, NED, MVD and coexistence of increased NED and MVD may be potential biochemical failure predictors. However, in the multivariate analysis, MVD was the only independent prognostic factor for biochemical failure. Conclusion: A high MVD index can estimate the risk for biochemical failure in clinically localized prostate cancer after radical prostatectomy. Copyright© 2007 International Institute of Anticancer Research (Dr. John G. Delinassios), All rights reserved