TY - JOUR T1 - Occurence of Stromal Myofibroblasts in the Invasive Ductal Breast Cancer Tissue is an Unfavourable Prognostic Factor JF - Anticancer Research JO - Anticancer Res SP - 2917 LP - 2924 VL - 27 IS - 4C AU - PAWEL SUROWIAK AU - DAWID MURAWA AU - VERENA MATERNA AU - ADAM MACIEJCZYK AU - MAREK PUDELKO AU - SLAWOMIR CIESLA AU - JAN BREBOROWICZ AU - PAWEL MURAWA AU - MACIEJ ZABEL AU - MANFRED DIETEL AU - HERMANN LAGE Y1 - 2007/07/01 UR - http://ar.iiarjournals.org/content/27/4C/2917.abstract N2 - Background: Numerous experimental studies have described the capacity of myofibroblasts to stimulate mammary cancer cells in a paracrine manner. Until now, the prognostic significance of myofibroblasts present in breast cancer has not been examined. Patients and Methods: In paraffin sections, originating from 45 patients with primary invasive breast cancer, immunohistochemical reactions were performed using antibodies directed against smooth muscle actin, Ki-67, VEGF, bFGF and UPA. Results: The cases with higher content of myofibroblasts in the tumour tissue manifested higher grade, more pronounced expression of Ki-67, VEGF and bFGF and shorter overall survival and relapse-free survival. Conclusion: The present study for the first time documents the unfavourable prognostic significance of myofibroblasts in tissues of invasive ductal mammary carcinomas. ER -