RT Journal Article SR Electronic T1 Association between Allelic Polymorphisms of Metabolizing Enzymes (CYP 1A1, CYP 1A2, CYP 2E1, mEH) and Occurrence of Colorectal Cancer in Hungary JF Anticancer Research JO Anticancer Res FD International Institute of Anticancer Research SP 2931 OP 2937 VO 27 IS 4C A1 ISTVÁN KISS A1 ZSUZSA ORSÓS A1 KATALIN GOMBOS A1 BARNA BOGNER A1 ANDRÁS CSEJTEI A1 ANTAL TIBOLD A1 ZSUZSA VARGA A1 EMESE PÁZSIT A1 INGRID MAGDA A1 ANNAMÁRIA ZÓLYOMI A1 ISTVÁN EMBER YR 2007 UL http://ar.iiarjournals.org/content/27/4C/2931.abstract AB Background: Genetic polymorphisms of metabolizing enzymes may affect the risk of cancer formation in humans. Since the diet can contain polycyclic aromatic hydrocarbons (PAHs) and heterocyclic amines (HAs), the relationship between polymorphisms of enzymes involved in PAH and HA metabolism and the occurrence of sporadic colorectal cancer was studied. Patients and Methods: Five hundred colorectal cancer patients and 500 controls were genotyped for cytochrome P450 enzymes (CYP) 1A1 Ile/Val, CYP 1A2*1F, CYP 2E1 c1/c2, microsomal epoxy hydrolase (mEH) exon 3 Tyr113His and exon 4 His139Arg polymorphisms by allele-specific polymerase chain reaction (PCR) or PCR-restriction fragmenth length polymorphism (RFLP). Results: The presence of CYP 1A1 Val, CYP 2E1 c2 and mEH exon 3 His alleles was statistically significantly associated with the occurrence of colorectal cancer (OR: 1.44 95% CI: 1.04-2.00; OR: 1.74 95% CI: 1.15-2.65; OR: 1.79 95% CI: 1.10-2.92, respectively). Conclusion: These findings suggest that allelic polymorphism of metabolizing enzymes play an important role in human colorectal carcinogenesis by affecting the metabolism of dietary carcinogens.