RT Journal Article
SR Electronic
T1 Association between Allelic Polymorphisms of Metabolizing Enzymes (CYP 1A1, CYP 1A2, CYP 2E1, mEH) and Occurrence of Colorectal Cancer in Hungary
JF Anticancer Research
JO Anticancer Res
FD International Institute of Anticancer Research
SP 2931
OP 2937
VO 27
IS 4C
A1 KISS, ISTVÁN
A1 ORSÓS, ZSUZSA
A1 GOMBOS, KATALIN
A1 BOGNER, BARNA
A1 CSEJTEI, ANDRÁS
A1 TIBOLD, ANTAL
A1 VARGA, ZSUZSA
A1 PÁZSIT, EMESE
A1 MAGDA, INGRID
A1 ZÓLYOMI, ANNAMÁRIA
A1 EMBER, ISTVÁN
YR 2007
UL http://ar.iiarjournals.org/content/27/4C/2931.abstract
AB Background: Genetic polymorphisms of metabolizing enzymes may affect the risk of cancer formation in humans. Since the diet can contain polycyclic aromatic hydrocarbons (PAHs) and heterocyclic amines (HAs), the relationship between polymorphisms of enzymes involved in PAH and HA metabolism and the occurrence of sporadic colorectal cancer was studied. Patients and Methods: Five hundred colorectal cancer patients and 500 controls were genotyped for cytochrome P450 enzymes (CYP) 1A1 Ile/Val, CYP 1A2*1F, CYP 2E1 c1/c2, microsomal epoxy hydrolase (mEH) exon 3 Tyr113His and exon 4 His139Arg polymorphisms by allele-specific polymerase chain reaction (PCR) or PCR-restriction fragmenth length polymorphism (RFLP). Results: The presence of CYP 1A1 Val, CYP 2E1 c2 and mEH exon 3 His alleles was statistically significantly associated with the occurrence of colorectal cancer (OR: 1.44 95% CI: 1.04-2.00; OR: 1.74 95% CI: 1.15-2.65; OR: 1.79 95% CI: 1.10-2.92, respectively). Conclusion: These findings suggest that allelic polymorphism of metabolizing enzymes play an important role in human colorectal carcinogenesis by affecting the metabolism of dietary carcinogens.