PT  - JOURNAL ARTICLE
AU  - SOON SUN KIM
AU  - JUNG WOO EUN
AU  - HYO JUNG CHO
AU  - HYUN-YOUNG LEE
AU  - CHUL WON SEO
AU  - CHOONG KYUN NOH
AU  - SUNG JAE SHIN
AU  - KEE MYUNG LEE
AU  - SUNG WON CHO
AU  - JAE YOUN CHEONG
TI  - Effect of Fibroblast Growth Factor-2 and its Receptor Gene Polymorphisms on the Survival of Patients With Hepatitis B Virus-associated Hepatocellular Carcinoma
AID  - 10.21873/anticanres.13337
DP  - 2019 Apr 01
TA  - Anticancer Research
PG  - 2217--2226
VI  - 39
IP  - 4
4099  - http://ar.iiarjournals.org/content/39/4/2217.short
4100  - http://ar.iiarjournals.org/content/39/4/2217.full
SO  - Anticancer Res2019 Apr 01; 39
AB  - Background/Aim: Fibroblast growth factor (FGF), vascular endothelial growth factor, and hepatocyte growth factor play a critical role in the pathogenesis of hepatocellular carcinoma (HCC). Materials and Methods: We assessed nine single nucleotide polymorphisms (SNPs) in the FGF1, FGF2, FGF receptor (FGFR)-2, Flt-1, and c-MET genes in 245 HCC patients and 483 chronic hepatitis B virus (HBV) carriers without HCC. Results: Kaplan–Meier analysis showed that patients with the FGF2 rs308447 TT genotype had shorter overall survival than patients with the CC or CT genotype (p=0.016) and that FGF2 rs308379 A allele carriers had shorter overall survival than patients with the TT genotype (p=0.020). Conclusion: Multivariate Cox proportional analysis revealed that the FGF2 rs308379 A allele (hazard ratio(HR)=1.663, p=0.004) and advanced tumor stage (HR=3.430, p<0.001) were independent prognostic factors for overall survival in patients with HCC.