TY - JOUR T1 - <em>Ulex europeus</em> Agglutinin-I Binding as a Potential Prognostic Marker in Ovarian Cancer JF - Anticancer Research JO - Anticancer Res SP - 2785 LP - 2790 VL - 27 IS - 4C AU - KATHARINA BLONSKI AU - KARIN MILDE-LANGOSCH AU - ANA-MARIA BAMBERGER AU - TINA OSTERHOLZ AU - CHRISTIAN UTLER AU - JÜRGEN BERGER AU - THOMAS LÖNING AU - UDO SCHUMACHER Y1 - 2007/07/01 UR - http://ar.iiarjournals.org/content/27/4C/2785.abstract N2 - Background: Ovarian cancer represents the malignant tumour of the female genital tract with the worst prognosis, mainly caused by early intraperitoneal spread. Cell-to-cell and cell-to-matrix interactions play a functionally important role in this spread and are both mediated by the cell membrane. Changes in the glycosylation of the cell membrane, as detected by lectin histochemistry, are sometimes associated with a poor prognosis. Patients and Methods: The expression of lectin binding of 164 ovarian cancer patients was analysed and the staining results were correlated with the clinical data of the patients. Results: The univariate and multivariate statistical analysis revealed an independent prognostic significance for Ulex europeus agglutinin-I (UEA-I) binding. Conclusion: These findings indicate that UEA-I binding can serve as a prognostic factor in ovarian cancer. ER -