TY - JOUR T1 - Adipose-specific Monocyte Chemotactic Protein-1 Deficiency Reduces Pulmonary Metastasis of Lewis Lung Carcinoma in Mice JF - Anticancer Research JO - Anticancer Res SP - 1729 LP - 1738 DO - 10.21873/anticanres.13279 VL - 39 IS - 4 AU - SNEHA SUNDARAM AU - LIN YAN Y1 - 2019/04/01 UR - http://ar.iiarjournals.org/content/39/4/1729.abstract N2 - Aim: Monocyte chemotactic protein-1 (MCP1) is a potent adipokine. This study tested the hypothesis that adipose-produced MCP1 contributes to metastasis. Materials and Methods: In a spontaneous metastasis model of Lewis lung carcinoma (LLC), male adipose MCP1-deficient (Mcp1−/−) and wild-type (WT) mice were fed the AIN93G diet or a high-fat diet (HFD) for 11 weeks. Lung metastasis from a subcutaneous tumor was the primary endpoint. Results: The adipose expression of MCP1 was lower in Mcp1−/− mice than in WT controls. The HFD increased the number of lung metastases in WT mice. The number of metastasis was significantly lower in the HFD-fed Mcp1−/− mice than in the HFD-fed WT mice. Compared to the WT mice, adipose MCP1 deficiency lowered plasma concentrations of insulin, proinflammatory adipokines (leptin, plasminogen activator inhibitor-1, and resistin), and angiogenic markers (vascular endothelial growth factor, hepatocyte growth factor, and angiopoietin-2). Conclusion: Adipose MCP1 deficiency attenuates HFD-enhanced pulmonary metastasis of LLC. ER -