TY - JOUR T1 - Chemosensitivity-related Genes of Breast Cancer Detected by DNA Microarray JF - Anticancer Research JO - Anticancer Res SP - 2649 LP - 2655 VL - 27 IS - 4C AU - TADASHI IKEDA AU - HIROMITSU JINNO AU - MASATOSHI SHIRANE Y1 - 2007/07/01 UR - http://ar.iiarjournals.org/content/27/4C/2649.abstract N2 - Background: The feasibility of a preoperative docetaxel/5′-deoxy-5-fluorouridine (5′-DFUR) regimen for breast cancer patients was examined and the genes related to the response to it was investigated. Patients and Methods: Women with advanced breast cancer were treated with docetaxel (60 mg/m2, day 1) and 5′-DFUR (800 mg/day, on days 1-14) q3 weeks by 4 cycles. Microarray analysis was carried out using preoperative core biopsy samples. Based on the mRNA expression levels, genes related to clinical and pathological responses were selected. Results: The docetaxel/5′-DFUR regimen showed a 86% clinical response rate including 42% complete response, one pathological complete response and one ductal carcinoma in situ component. In microarray analysis, we identified 6 genes, including IGF-1, and derived a predictive formula with 67% accuracy. In addition, χ2 analysis revealed a tendency for good response in ER-negative and Her2/neu-positive cases. Conclusion: Microarray analysis enabled us to predict the pathological response to docetaxel/5′-DFUR chemotherapy. ER -