PT  - JOURNAL ARTICLE
AU  - KIM, HONG-BEUM
AU  - CHOI, WOO YOUNG
AU  - KIM, SEONG-HUN
AU  - LEE, HEE-JEONG
AU  - PARK, SANG-GON
TI  - GNAO1: A Novel Tumor Suppressor Gene in Colorectal Cancer Pathogenesis
AID  - 10.21873/anticanres.17368
DP  - 2024 Dec 01
TA  - Anticancer Research
PG  - 5425--5433
VI  - 44
IP  - 12
4099  - http://ar.iiarjournals.org/content/44/12/5425.short
4100  - http://ar.iiarjournals.org/content/44/12/5425.full
SO  - Anticancer Res2024 Dec 01; 44
AB  - Background/Aim: This study examined the role of GNAO1 as a potential tumor suppressor gene in colorectal cancer (CRC). Materials and Methods: RNA-seq data analysis revealed a significant GNAO1 down-regulation in colon cancer tissues compared to normal colon tissues. Results: GNAO1 over-expression in CRC cell lines inhibited cell proliferation, migration, and tumor formation both in vitro and in vivo. This study suggests that GNAO1 exerts its tumor-suppressive effects by inhibiting the mTOR/S6K signaling pathway. The observed correlation between GNAO1 expression and cancer progression highlights its potential as a prognostic marker and therapeutic target in CRC. Conclusion: This study provides a foundation for further exploration of the molecular mechanisms by which GNAO1 influences CRC pathogenesis, with significant implications for its application in clinical settings.