RT Journal Article SR Electronic T1 IL6 Shapes an Inflammatory Microenvironment and Triggers the Development of Unique Types of Cancer in End-stage Kidney JF Anticancer Research JO Anticancer Res FD International Institute of Anticancer Research SP 1869 OP 1874 DO 10.21873/anticanres.13294 VO 39 IS 4 A1 LEHEL PETERFI A1 MARIA V. YUSENKO A1 GYULA KOVACS YR 2019 UL http://ar.iiarjournals.org/content/39/4/1869.abstract AB Background/Aim: Chronic inflammation in end-stage kidney is associated with the development of pre-neoplastic lesions and renal cell tumors. The aim of this study was to clarify the role of the inflammatory microenvironment in this process. Materials and Methods: We used representative microscopic slides from 11 end stage-kidneys containing pre-neoplastic lesions and tumors and applied immunohistochemistry to detect IL-6, SAA1 and LBP expression. We also applied array-based comparative genomic hybridization (CGH) analysis to detect genomic changes in tumor cells. Results: We identified strong expression of IL6, LBP and SAA1 in activated stromal fibroblasts, in proliferating epithelial and tumor cells. Array CGH detected unusual genomic changes in tumor cells. Conclusion: Our data indicate that expression of IL6, acute phase protein SAA1 and LBP maintain a long-lasting inflammatory microenvironment that leads to remodeling of end-stage kidneys and the development of unique types of renal cell tumors.