<?xml version='1.0' encoding='UTF-8'?><xml><records><record><source-app name="HighWire" version="7.x">Drupal-HighWire</source-app><ref-type name="Journal Article">17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">PARK, HYE MI</style></author><author><style face="normal" font="default" size="100%">HONG, SEUNG HO</style></author><author><style face="normal" font="default" size="100%">KIM, JONG WOO</style></author><author><style face="normal" font="default" size="100%">OH, DOYEUN</style></author><author><style face="normal" font="default" size="100%">HWANG, SEONG GYU</style></author><author><style face="normal" font="default" size="100%">AN, HEE JUNG</style></author><author><style face="normal" font="default" size="100%">KIM, NAM KEUN</style></author></authors><secondary-authors></secondary-authors></contributors><titles><title><style face="normal" font="default" size="100%">Gender-specific Association of the &lt;em&gt;VEGF&lt;/em&gt; -2578C&amp;gt;A Polymorphism in Korean Patients with Colon Cancer</style></title><secondary-title><style face="normal" font="default" size="100%">Anticancer Research</style></secondary-title></titles><dates><year><style  face="normal" font="default" size="100%">2007</style></year><pub-dates><date><style  face="normal" font="default" size="100%">2007-07-01 00:00:00</style></date></pub-dates></dates><pages><style  face="normal" font="default" size="100%">2535-2539</style></pages><volume><style face="normal" font="default" size="100%">27</style></volume><issue><style face="normal" font="default" size="100%">4B</style></issue><abstract><style  face="normal" font="default" size="100%">Background: Angiogenesis is involved in the development of cancer, promoting tumor growth, invasiveness and metastasis. Vascular endothelial growth factor (VEGF) is a potent angiogenic factor. The present case control study was carried out, to determine whether there is an association between the VEGF -2578C&gt;A polymorphism and colon cancer. Patients and Methods: DNA samples taken from 246 patients with colon cancer and 203 healthy controls were amplified by polymerase chain reaction for VEGF -2578C&gt;A polymorphism. Results: Genotype frequencies of the VEGF -2578C&gt;A polymorphism were not significantly different between patient and control groups. However, when the data were stratified by gender, the frequency of the -2578CA+AA (A allele-bearing) genotype was marginally significant different with protective effect for colon cancer in women (odds ratio, OR, 0.60; 95% confidence interval, CI, 0.36-0.99; p=0.056). The -2578CA+AA genotype was also associated with reduced risk in patients with proximal colon cancer (OR, 0.55; 95% CI, 0.31-0.97; p=0.049). This association also remained in women with proximal colon cancer. Conclusion: Although the VEGF -2578C&gt;A polymorphism had no influence on susceptibility to colon cancer, some genotypes showed a significant difference between the case and control groups when the data were stratified by gender and the original location of tumor, suggesting that the VEGF -2578C&gt;A polymorphism, at least in Koreans, is a genetic determinant of colon cancer risk. Copyright© 2007 International Institute of Anticancer Research (Dr. John G. Delinassios), All rights reserved</style></abstract></record></records></xml>