RT Journal Article
SR Electronic
T1 Coagulation-related Factors, Thrombomodulin and Protein Z, are not Associated with Risk for Oral Cancer
JF Anticancer Research
JO Anticancer Res
FD International Institute of Anticancer Research
SP 2449
OP 2451
VO 27
IS 4B
A1 VAIRAKTARIS, ELEFTHERIOS
A1 SEREFOGLOU, ZOE
A1 YAPIJAKIS, CHRISTOS
A1 NKENKE, EMEKA
A1 VASSILIOU, STAVROS
A1 SPYRIDONIDOU, SOFIA
A1 VYLLIOTIS, ANTONIS
A1 NIXON, ALEXANDER MICHAEL
A1 NEUKAM, FRIEDRICH WILHELM
A1 PATSOURIS, EFSTRATIOS
YR 2007
UL http://ar.iiarjournals.org/content/27/4B/2449.abstract
AB Background: The link between thrombosis and cancer has been well established. Levels of protein Z and thrombomodulin indirectly regulate thrombin productionl and therefore may affect cancer susceptibility. Patients and Methods: The functional polymorphisms -13A/G and -33G/A in protein Z and thrombomodulin genes (respectively) influence transcription. The two polymorphisms were investigated in 160 oral cancer patients and 168 controls of equivalent age, gender and ethnicity using restriction fragment length polymorphism typing. Results: The frequency of the -13G allele, which results in lower expression of protein Z gene, was not significantly elevated in patients compared to controls (8.1% and 6.3%, respectively; odds ratio 1.35, 95% confidence interval 0.72-2.56). No carriers of the thrombomodulin low expression -33A allele were identified, underscoring the rarity of this allele in Caucasians. Conclusion: Inherited predisposition affecting protein Z or thrombomodulin levels does not modulate susceptibility to oral cancer. Any possible contribution of thrombin to oral oncogenesis may involve other factors. Copyright© 2007 International Institute of Anticancer Research (Dr. John G. Delinassios), All rights reserved