TY - JOUR T1 - Characterization of Bone Lesions in Myeloma Before and During Anticancer Therapy Using <sup>18</sup>F-FDG-PET/CT and <sup>18</sup>F-NaF-PET/CT JF - Anticancer Research JO - Anticancer Res SP - 1943 LP - 1952 DO - 10.21873/anticanres.13304 VL - 39 IS - 4 AU - THOMAS SELIM NAKUZ AU - FILIPE PORTELA MILLINGER AU - KAREM EL-RABADI AU - MICHAEL WEBER AU - VERENA PICHLER AU - WOLFGANG WADSAK AU - MARKUS MITTERHAUSER AU - ALEXANDER HAUG AU - MARCUS HACKER AU - GEORGIOS KARANIKAS AU - PETER PIETSCHMANN AU - HERMINE AGIS Y1 - 2019/04/01 UR - http://ar.iiarjournals.org/content/39/4/1943.abstract N2 - Background: The objective of this study was to characterize tumor activity and mineralization status in newly-detected multiple myeloma (MM) bone lesions using 2-18F-fluoro-2-deoxy-D-glucose (18F-FDG)-PET/CT and 18F-sodium fluoride (18F-NaF)-PET/CT before and after antitumor treatment. Materials and Methods: In this retrospective study, seven patients with histologically-verified MM were included (four women, three men; median age=57 years, standard deviation=11.23 years). PET/CT was performed with 18F-FDG and with 18F-NaF, both at baseline and after treatment. All patients had positive scans. Volumes of interest (VOIs) were drawn over all 18F-FDG-PET/CT-positive bone lesions, as well as the corresponding regions in 18F-NaF-PET/CT. For characterization of bone lesions, semi-quantitative standard uptake value (SUV) parameters were measured. Results: 18F-FDG-PET/CT in the seven patients detected 39 metabolically active lesions that were correlated with the corresponding sites in 18F-fluoride-PET/CT. Overall, the lesions showed a response to therapy, with a significant decrease in SUVmax on PET/CT using 18F-FDG (p&lt;0.001) and with 18F-NaF (p&lt;0.001). In four patients with a second follow-up scan (at a median of 17 months after baseline scan), there was no significant change in lesion uptake. Conclusion: Based on our data, antitumor therapy in MM reduces not only tumor activity, but also the mineralization status of bone lesions. A second follow-up scan in a subset of the cohort yielded no change in mineralization status. ER -