RT Journal Article
SR Electronic
T1 Prognostic Significance of Platelet-derived Growth Factor-BB Expression in Human Esophageal Squamous Cell Carcinomas
JF Anticancer Research
JO Anticancer Res
FD International Institute of Anticancer Research
SP 2409
OP 2414
VO 27
IS 4B
A1 MATSUMOTO, SOHEI
A1 YAMADA, YUKISHIGE
A1 NARIKIYO, MICHIHIRO
A1 UENO, MASATO
A1 TAMAKI, HIDETOSHI
A1 MIKI, KATSUHIKO
A1 WAKATSUKI, KOHEI
A1 ENOMOTO, KOJI
A1 YOKOTANI, TOMOYO
A1 NAKAJIMA, YOSHIYUKI
YR 2007
UL http://ar.iiarjournals.org/content/27/4B/2409.abstract
AB Background: Cancer metastases are commonly found in the lymphatic system and tumor lymphangiogenesis requires the interplay of several growth factors. The expression of platelet-derived growth factor (PDGF)-BB and vascular endothelial growth factor (VEGF)-C in esophageal cancer was investigated to define their clinicopathological significance. Materials and Methods: Using immunohistochemistry, the expression of PDGF-BB and VEGF-C was examined, along with lymphatic vessel density (LVD) in 53 patients with esophageal cancer. Results: PDGF-BB and VEGF-C expression was positive in 31 cases (58.5%) and 38 cases (71.7%), respectively, and expression correlated with lymph node metastasis and lymphatic invasion. Furthermore, PDGF-BB expression correlated with the depth of tumor invasion and the size of the tumor, and PDGF-BB-positive patients had a significantly poorer prognosis than PDGF-BB-negative patients. The LVD in positive PDGF-BB or VEGF-C tumors was higher than in negative tumors. Conclusion: PDGF-BB may play a pivotal role in lymphangiogenesis and tumor growth in esophageal cancer. Copyright© 2007 International Institute of Anticancer Research (Dr. John G. Delinassios), All rights reserved