<?xml version='1.0' encoding='UTF-8'?><xml><records><record><source-app name="HighWire" version="7.x">Drupal-HighWire</source-app><ref-type name="Journal Article">17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">MATSUMOTO, SOHEI</style></author><author><style face="normal" font="default" size="100%">YAMADA, YUKISHIGE</style></author><author><style face="normal" font="default" size="100%">NARIKIYO, MICHIHIRO</style></author><author><style face="normal" font="default" size="100%">UENO, MASATO</style></author><author><style face="normal" font="default" size="100%">TAMAKI, HIDETOSHI</style></author><author><style face="normal" font="default" size="100%">MIKI, KATSUHIKO</style></author><author><style face="normal" font="default" size="100%">WAKATSUKI, KOHEI</style></author><author><style face="normal" font="default" size="100%">ENOMOTO, KOJI</style></author><author><style face="normal" font="default" size="100%">YOKOTANI, TOMOYO</style></author><author><style face="normal" font="default" size="100%">NAKAJIMA, YOSHIYUKI</style></author></authors><secondary-authors></secondary-authors></contributors><titles><title><style face="normal" font="default" size="100%">Prognostic Significance of Platelet-derived Growth Factor-BB Expression in Human Esophageal Squamous Cell Carcinomas</style></title><secondary-title><style face="normal" font="default" size="100%">Anticancer Research</style></secondary-title></titles><dates><year><style  face="normal" font="default" size="100%">2007</style></year><pub-dates><date><style  face="normal" font="default" size="100%">2007-07-01 00:00:00</style></date></pub-dates></dates><pages><style  face="normal" font="default" size="100%">2409-2414</style></pages><volume><style face="normal" font="default" size="100%">27</style></volume><issue><style face="normal" font="default" size="100%">4B</style></issue><abstract><style  face="normal" font="default" size="100%">Background: Cancer metastases are commonly found in the lymphatic system and tumor lymphangiogenesis requires the interplay of several growth factors. The expression of platelet-derived growth factor (PDGF)-BB and vascular endothelial growth factor (VEGF)-C in esophageal cancer was investigated to define their clinicopathological significance. Materials and Methods: Using immunohistochemistry, the expression of PDGF-BB and VEGF-C was examined, along with lymphatic vessel density (LVD) in 53 patients with esophageal cancer. Results: PDGF-BB and VEGF-C expression was positive in 31 cases (58.5%) and 38 cases (71.7%), respectively, and expression correlated with lymph node metastasis and lymphatic invasion. Furthermore, PDGF-BB expression correlated with the depth of tumor invasion and the size of the tumor, and PDGF-BB-positive patients had a significantly poorer prognosis than PDGF-BB-negative patients. The LVD in positive PDGF-BB or VEGF-C tumors was higher than in negative tumors. Conclusion: PDGF-BB may play a pivotal role in lymphangiogenesis and tumor growth in esophageal cancer. Copyright© 2007 International Institute of Anticancer Research (Dr. John G. Delinassios), All rights reserved</style></abstract></record></records></xml>