RT Journal Article
SR Electronic
T1 Galectin-3 Expression in Colorectal Cancer: Relation to Invasion and Metastasis
JF Anticancer Research
JO Anticancer Res
FD International Institute of Anticancer Research
SP 2289
OP 2296
VO 27
IS 4B
A1 TSUBOI, KAORI
A1 SHIMURA, TATSUO
A1 MASUDA, NORIHIRO
A1 IDE, MUNENORI
A1 TSUTSUMI, SOICHI
A1 YAMAGUCHI, SATORU
A1 ASAO, TAKAYUI
A1 KUWANO, HIROYUKI
YR 2007
UL http://ar.iiarjournals.org/content/27/4B/2289.abstract
AB Background: Galectin-3, a β-galactoside-binding protein, has been associated with various biological processes, such as cell adhesion, recognition, proliferation, differentiation and apoptosis. The aim of this study was to determine the relationship of galectin-3 expression to clinicopathological findings in patients with colorectal cancer. Furthermore, the correlation between the expression of galectin-3 and β-catenin, and the Ki-67 labeling index were investigated. Materials and Methods: Immunohistochemical assessment of galectin-3, β-catenin and Ki-67 expression was performed on samples from 108 patients with colorectal cancer. The expression of galectin-3 was classified at the tumor surface and the invasive front, and its relationship with clinicopathological factors was considered from a statistical viewpoint. Results: There was significant liver metastasis when the expression of galectin-3 was lower at the invasive front of a tumor compared to its surface (p=0.04). There were also significant correlations between β-catenin expression at the tumor surface and liver metastasis and tumor stage (p=0.03, p=0.04 respectively). Conclusion: The reduction of galectin-3 expression is associated with the invasion and metastasis of colorectal cancer. A possible involvement of galectin-3 expression in tumor invasion, metastasis and proliferation in patients with colorectal cancer is suggested. Copyright© 2007 International Institute of Anticancer Research (Dr. John G. Delinassios), All rights reserved