<?xml version='1.0' encoding='UTF-8'?><xml><records><record><source-app name="HighWire" version="7.x">Drupal-HighWire</source-app><ref-type name="Journal Article">17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">TSUBOI, KAORI</style></author><author><style face="normal" font="default" size="100%">SHIMURA, TATSUO</style></author><author><style face="normal" font="default" size="100%">MASUDA, NORIHIRO</style></author><author><style face="normal" font="default" size="100%">IDE, MUNENORI</style></author><author><style face="normal" font="default" size="100%">TSUTSUMI, SOICHI</style></author><author><style face="normal" font="default" size="100%">YAMAGUCHI, SATORU</style></author><author><style face="normal" font="default" size="100%">ASAO, TAKAYUI</style></author><author><style face="normal" font="default" size="100%">KUWANO, HIROYUKI</style></author></authors><secondary-authors></secondary-authors></contributors><titles><title><style face="normal" font="default" size="100%">Galectin-3 Expression in Colorectal Cancer: Relation to Invasion and Metastasis</style></title><secondary-title><style face="normal" font="default" size="100%">Anticancer Research</style></secondary-title></titles><dates><year><style  face="normal" font="default" size="100%">2007</style></year><pub-dates><date><style  face="normal" font="default" size="100%">2007-07-01 00:00:00</style></date></pub-dates></dates><pages><style  face="normal" font="default" size="100%">2289-2296</style></pages><volume><style face="normal" font="default" size="100%">27</style></volume><issue><style face="normal" font="default" size="100%">4B</style></issue><abstract><style  face="normal" font="default" size="100%">Background: Galectin-3, a β-galactoside-binding protein, has been associated with various biological processes, such as cell adhesion, recognition, proliferation, differentiation and apoptosis. The aim of this study was to determine the relationship of galectin-3 expression to clinicopathological findings in patients with colorectal cancer. Furthermore, the correlation between the expression of galectin-3 and β-catenin, and the Ki-67 labeling index were investigated. Materials and Methods: Immunohistochemical assessment of galectin-3, β-catenin and Ki-67 expression was performed on samples from 108 patients with colorectal cancer. The expression of galectin-3 was classified at the tumor surface and the invasive front, and its relationship with clinicopathological factors was considered from a statistical viewpoint. Results: There was significant liver metastasis when the expression of galectin-3 was lower at the invasive front of a tumor compared to its surface (p=0.04). There were also significant correlations between β-catenin expression at the tumor surface and liver metastasis and tumor stage (p=0.03, p=0.04 respectively). Conclusion: The reduction of galectin-3 expression is associated with the invasion and metastasis of colorectal cancer. A possible involvement of galectin-3 expression in tumor invasion, metastasis and proliferation in patients with colorectal cancer is suggested. Copyright© 2007 International Institute of Anticancer Research (Dr. John G. Delinassios), All rights reserved</style></abstract></record></records></xml>