PT - JOURNAL ARTICLE AU - MORIKAZU MIYAMOTO AU - MASASHI TAKANO AU - HITOSHI TSUDA AU - HIROKI ISHIBASHI AU - HIROAKI SOYAMA AU - HIROKO MATSUURA AU - TAKAHIRO SAKAMOTO AU - TADASHI AOYAMA AU - HIDEKI IWAHASHI AU - KENICHI FURUYA TI - Zone Formation of Lymphocyte Infiltration at the Invasive Front Results in the Prolonged Survival of Individuals With Endometrial Serous Carcinoma and Endometrioid Carcinoma With Serous Component AID - 10.21873/anticanres.13320 DP - 2019 Apr 01 TA - Anticancer Research PG - 2085--2089 VI - 39 IP - 4 4099 - http://ar.iiarjournals.org/content/39/4/2085.short 4100 - http://ar.iiarjournals.org/content/39/4/2085.full SO - Anticancer Res2019 Apr 01; 39 AB - Background/Aim: This study aimed to evaluate the clinical significance of lymphocyte infiltration (LI) for patients with endometrial serous carcinoma and those with endometrioid carcinoma including serous component. Patients and Methods: Patients who underwent surgery at our hospital between 1990 and 2013 were identified. LI was classified into strong LI, defined as a continuous thick zone of LI, and weak LI, defined as the lack of zone or scattered small foci of LI at the invasive front. Results: Out of a total of 51 patients, 38 cases had weak LI and 13 had strong LI. The progression-free survival of patients with weak LI was worse (p=0.02). No significant difference of overall survival according to the status of LI was noted (p=0.054). Multivariate analysis revealed that LI was a prognostic factor of poorer progression-free survival (hazard ratio(HR)=5.05, p<0.01) and overall survival (HR=6.93, p=0.01). Conclusion: LI might be a new biomarker of such conditions.