RT Journal Article
SR Electronic
T1 Alterations of the Glymphatic System in Glioblastomas: A Systematic Review
JF Anticancer Research
JO Anticancer Res
FD International Institute of Anticancer Research
SP 3223
OP 3230
DO 10.21873/anticanres.17140
VO 44
IS 8
A1 SCALIA, GIANLUCA
A1 FERINI, GIANLUCA
A1 SILVEN, MANIKON PULLAY
A1 NOTO, MANFREDI
A1 COSTANZO, ROBERTA
A1 MAUGERI, ROSARIO
A1 IACOPINO, DOMENICO GERARDO
A1 ZAGARDO, VALENTINA
A1 VIOLA, ANNA
A1 NICOLETTI, GIOVANNI FEDERICO
A1 UMANA, GIUSEPPE EMMANUELE
YR 2024
UL http://ar.iiarjournals.org/content/44/8/3223.abstract
AB Background/Aim: The glioblastomas, aggressive brain tumors with a poor prognosis, have drawn interest in their interaction with the glymphatic system—an emerging brain drainage network. This review explores the relationship between glioblastomas and the glymphatic system, aiming to elucidate their impact on disease progression. The aim of the study was to address the alterations in the glymphatic system in the presence of glioblastoma, and their implications for disease pathogenesis and prognosis. Materials and Methods: Following PRISMA guidelines, we conducted a systematic literature review, identifying studies on the glymphatic system in glioblastomas. Four high-quality studies were selected based on stringent criteria. Data extraction involved categorizing key findings, and thematic analysis uncovered recurring patterns in glymphatic alterations associated with glioblastomas. Results: Out of 356 studies, four meeting the high-quality criteria were included. These studies revealed modifications in lymphatic outflow, factors contributing to glymphatic dysfunction, impediments to cerebrospinal fluid drainage, and emerging roles in glioma management. The findings allow a comprehensive understanding of alterations within the glymphatic system in the presence of glioblastoma. Conclusion: The glymphatic system in glioblastomas exhibits changes, including diminished lymphatic outflow, disruptions and obstacles to fluid drainage, which represent new dimensions in glioma management. These alterations affect drug delivery, immunotherapy, and imaging interpretation. Future research should prioritize elucidating molecular mechanisms, developing therapeutic strategies, optimizing drug delivery, exploring immunotherapy, and translating findings into clinical practice.