RT Journal Article SR Electronic T1 Chromosomal Aneusomy (Chr 1, 11, 17) Detected by Fluorescence In Situ Hybridization May be a Prognostic Factor in Breast Cancer JF Anticancer Research JO Anticancer Res FD International Institute of Anticancer Research SP 1073 OP 1078 VO 27 IS 2 A1 TAKEHISA, MASATSUGU A1 SASA, MITSUNORI A1 BANDO, YOSHIMI A1 HIROSE, TOSHIYUKI A1 MORIMOTO, TADAOKI A1 NAGAO, TAEKO A1 TANGOKU, AKIRA YR 2007 UL http://ar.iiarjournals.org/content/27/2/1073.abstract AB The relationship between clinicopathological findings and the long-term prognosis was investigated in 42 breast cancer patients in whom aneusomy was detected for chromosomes 1, 11 and 17. The frequencies of aneusomy of those chromosomes were 78.6%, 47.5% and 52.5%, respectively, and more than 90% of anomalies consisted of polysomy. The relationship between aneusomy and the clinicopathological findings showed a statistical correlation with a high histological grade in the case of polysomy of chromosome 17 compared with disomy, indicating a tendency for a high incidence of lymph node metastasis. Analysis of the survival data revealed that the prognosis was poor when there was polysomy of chromosomes 1 or 11. These results indicate the possibility that aneusomy of chromosomes 1, 11 and 17 can serve as prognostic factors of poor outcome in breast cancer patients. Copyright© 2007 International Institute of Anticancer Research (Dr. John G. Delinassios), All rights reserved