PT  - JOURNAL ARTICLE
AU  - TAKEHISA, MASATSUGU
AU  - SASA, MITSUNORI
AU  - BANDO, YOSHIMI
AU  - HIROSE, TOSHIYUKI
AU  - MORIMOTO, TADAOKI
AU  - NAGAO, TAEKO
AU  - TANGOKU, AKIRA
TI  - Chromosomal Aneusomy (Chr 1, 11, 17) Detected by Fluorescence <em>In Situ</em> Hybridization May be a Prognostic Factor in Breast Cancer
DP  - 2007 Mar 01
TA  - Anticancer Research
PG  - 1073--1078
VI  - 27
IP  - 2
4099  - http://ar.iiarjournals.org/content/27/2/1073.short
4100  - http://ar.iiarjournals.org/content/27/2/1073.full
SO  - Anticancer Res2007 Mar 01; 27
AB  - The relationship between clinicopathological findings and the long-term prognosis was investigated in 42 breast cancer patients in whom aneusomy was detected for chromosomes 1, 11 and 17. The frequencies of aneusomy of those chromosomes were 78.6%, 47.5% and 52.5%, respectively, and more than 90% of anomalies consisted of polysomy. The relationship between aneusomy and the clinicopathological findings showed a statistical correlation with a high histological grade in the case of polysomy of chromosome 17 compared with disomy, indicating a tendency for a high incidence of lymph node metastasis. Analysis of the survival data revealed that the prognosis was poor when there was polysomy of chromosomes 1 or 11. These results indicate the possibility that aneusomy of chromosomes 1, 11 and 17 can serve as prognostic factors of poor outcome in breast cancer patients. Copyright© 2007 International Institute of Anticancer Research (Dr. John G. Delinassios), All rights reserved