RT Journal Article
SR Electronic
T1 Maspin Expression in Adenocarcinoma of the Ampulla of Vater: Relation with Clinicopathological Parameters and Apoptosis
JF Anticancer Research
JO Anticancer Res
FD International Institute of Anticancer Research
SP 1059
OP 1065
VO 27
IS 2
A1 BLANDAMURA, STELLA
A1 D'ALESSANDRO, EMILIANO
A1 GUZZARDO, VINCENZA
A1 GIACOMELLI, LUCIANO
A1 MOSCHINO, PAOLO
A1 PARENTI, ANNA
A1 NINFO, VITO
YR 2007
UL http://ar.iiarjournals.org/content/27/2/1059.abstract
AB Aim: Maspin is a unique serine proteinase inhibitor which has tumor suppressor activity. The aim of the present study was to investigate the role of maspin in ampullary adenocarcinomas, its correlation with apoptosis and its value as a prognostic marker. Patients and Methods: Twenty-three cases of ampulla of Vater adenocarcinoma were collected from archival material. For each sample, maspin, M30, p53 and Mib1 immunohistochemical reactivity were evaluated and results compared with clinicopathological parameters. Results: A statistical relation was found between nuclear maspin and M30 (Spearman's ϱ=0.46, p=0.02), and p53 (Kruskal-Wallis=0.03); a trend was found between nuclear maspin and pT (Kruskal-Wallis=0.09), and pM (Mann-Whitney=0.08) and pN status (Fisher's mid-point test: p=0.070). Conclusion: The present study evaluated the role of maspin in ampullary adenocarcinomas and for the first time demonstrated its association with apoptosis, tumor growth and metastasis. Copyright© 2007 International Institute of Anticancer Research (Dr. John G. Delinassios), All rights reserved