<?xml version='1.0' encoding='UTF-8'?><xml><records><record><source-app name="HighWire" version="7.x">Drupal-HighWire</source-app><ref-type name="Journal Article">17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">NA, YONG MIN</style></author><author><style face="normal" font="default" size="100%">PARK, SANG CHUN</style></author><author><style face="normal" font="default" size="100%">RYU, YOUNG JAE</style></author><author><style face="normal" font="default" size="100%">CHO, JIN SEONG</style></author><author><style face="normal" font="default" size="100%">PARK, MIN HO</style></author></authors><secondary-authors></secondary-authors></contributors><titles><title><style face="normal" font="default" size="100%">Risk Factors for Non-sentinel Lymph Node Metastasis in HR+/HER2− Breast Cancer With cN0</style></title><secondary-title><style face="normal" font="default" size="100%">Anticancer Research</style></secondary-title></titles><dates><year><style  face="normal" font="default" size="100%">2024</style></year><pub-dates><date><style  face="normal" font="default" size="100%">2024-08-01 00:00:00</style></date></pub-dates></dates><pages><style  face="normal" font="default" size="100%">3493-3500</style></pages><doi><style  face="normal" font="default" size="100%">10.21873/anticanres.17169</style></doi><volume><style face="normal" font="default" size="100%">44</style></volume><issue><style face="normal" font="default" size="100%">8</style></issue><abstract><style  face="normal" font="default" size="100%">Background/Aim: This study aimed to identify the risk factors associated with non-sentinel lymph node (non-SLN) metastasis in case of hormone receptor (HR)-positive, human epidermal growth factor receptor 2 (HER2)-negative breast cancer with cN0 on preoperative exam, where the sentinel lymph node (SLN) is positive. Patients and Methods: We conducted a retrospective review of medical records from the Chonnam National University Hwasun Hospital, spanning from January 2013 to January 2020, focusing on patients with HR+, HER2− breast cancer. Specifically, we collected the clinical and pathological data for those patients who underwent axillary lymph node dissection (ALND) due to positive SLN. Results: Among the 166 patients who underwent ALND after positive SLNs, median patient age was 52 years. Univariate analyses demonstrated a significant association between non-SLN metastasis and the number of positive SLNs (p=0.039), SLN positive ratio (p&lt;0.001), and primary tumor size (p=0.018). Multivariate analysis revealed that an SLN ratio &gt;0.55 (p=0.004, HR=3.007, 95% CI=1.427-6.335) was independently associated with non-SLN metastasis. However, neither the number of positive SLN nor primary tumor size showed associations with non-SLN metastases. Conclusion: In patients with HR+, HER2− breast cancer who are cN0, completion of ALND should be considered when the positive SLN ratio is ≥0.55. This approach aims to provide the opportunity for survival benefit through additional adjuvant therapy or to contribute to de-escalation of unnecessary surgery.</style></abstract></record></records></xml>