TY - JOUR T1 - Prognostic Roles of SCC Antigen, CRP and CYFRA 21-1 in Oral Cavity Squamous Cell Carcinoma JF - Anticancer Research JO - Anticancer Res SP - 2025 LP - 2033 DO - 10.21873/anticanres.13313 VL - 39 IS - 4 AU - DANTE DE PAZ AU - CHI-KUANG YOUNG AU - HUEI-TZU CHIEN AU - CHUNG-KANG TSAO AU - CHEONG CHON FOK AU - KANG-HSING FAN AU - CHUN-TA LIAO AU - HUNG-MING WANG AU - CHUNG-JAN KANG AU - JOSEPH TUNG-CHIEH CHANG AU - SHIANG-FU HUANG Y1 - 2019/04/01 UR - http://ar.iiarjournals.org/content/39/4/2025.abstract N2 - Background/Aim: Tumor-related and inflammation-related markers were reported to be prognostic in cancer patients. In this study, we evaluated squamous cell carcinoma antigen (SCC-Ag), cytokeratin 19 fragment (CYFRA 21-1) and C-reactive protein (CRP) simultaneously in oral cavity squamous cell carcinoma (OSCC) patients. Patients and Methods: Two hundred and forty-six newly diagnosed OSCC patients were retrospectively recruited between December 2010 and December 2016. Results: The elevation of CRP levels (≥5.0 mg/l) and SCC-Ag levels (≥2.0 ng/ml) were significantly related with tumor invasion parameters and metastatic factors. In contrast, the elevation of CYFRA 21-1 levels (≥3.3 ng/ml) was related with extranodal extension alone. For patients with all three markers being elevated before surgery, their overall survival and disease-free survival were significantly worse than others. Conclusion: Concurrent elevation of preoperative SCC-Ag, CYFRA 21-1 and CRP serum levels can be correlated with worse survival rates in OSCC. ER -