RT Journal Article SR Electronic T1 Effect of Ganoderma lucidum on Cisplatin-induced Nephrotoxicity and Gastrointestinal Toxicity JF Anticancer Research JO Anticancer Res FD International Institute of Anticancer Research SP 3605 OP 3613 DO 10.21873/anticanres.17183 VO 44 IS 8 A1 OTA, NATSUKI A1 ENDO, SHOYA A1 TATSUNAMI, RYOSUKE A1 YAMAGUCHI, AOI A1 WAKAME, KOJI A1 NAKATA, AKIFUMI A1 SATO, KEISUKE YR 2024 UL http://ar.iiarjournals.org/content/44/8/3605.abstract AB Background/Aim: Cancer remains a major global health challenge, with an estimated 10 million cancer-related deaths in 2020, hindering efforts to extend life expectancy. Cisplatin, an effective platinum-based chemotherapeutic agent used against various malignancies, has numerous side effects. Ganoderma lucidum is a traditional Chinese medicine with extensive historical use and proven biological activity. This study investigated the effects of G. lucidum on cisplatin-induced nephrotoxicity and gastrointestinal toxicity. Materials and Methods: RAW264.7 cells were treated with cisplatin, G. lucidum, or both. Cytotoxicity and antioxidant capacity were measured. Slc:ICR (ICR) mice were treated with cisplatin, G. lucidum, or both. The survival rate and physiological data were measured. Results: G. lucidum suppressed cisplatin-induced cytotoxicity and apoptosis in RAW264.7 cells. G. lucidum suppressed cisplatin-induced nephrotoxicity and gastrointestinal toxicity via its antioxidant effects in ICR mice. Conclusion: The suppressive mechanism of G. lucidum may be mediated via its antioxidant effects. These findings indicate its potential to reduce the side effects of cisplatin.