PT  - JOURNAL ARTICLE
AU  - OTA, NATSUKI
AU  - ENDO, SHOYA
AU  - TATSUNAMI, RYOSUKE
AU  - YAMAGUCHI, AOI
AU  - WAKAME, KOJI
AU  - NAKATA, AKIFUMI
AU  - SATO, KEISUKE
TI  - Effect of <em>Ganoderma lucidum</em> on Cisplatin-induced Nephrotoxicity and Gastrointestinal Toxicity
AID  - 10.21873/anticanres.17183
DP  - 2024 Aug 01
TA  - Anticancer Research
PG  - 3605--3613
VI  - 44
IP  - 8
4099  - http://ar.iiarjournals.org/content/44/8/3605.short
4100  - http://ar.iiarjournals.org/content/44/8/3605.full
SO  - Anticancer Res2024 Aug 01; 44
AB  - Background/Aim: Cancer remains a major global health challenge, with an estimated 10 million cancer-related deaths in 2020, hindering efforts to extend life expectancy. Cisplatin, an effective platinum-based chemotherapeutic agent used against various malignancies, has numerous side effects. Ganoderma lucidum is a traditional Chinese medicine with extensive historical use and proven biological activity. This study investigated the effects of G. lucidum on cisplatin-induced nephrotoxicity and gastrointestinal toxicity. Materials and Methods: RAW264.7 cells were treated with cisplatin, G. lucidum, or both. Cytotoxicity and antioxidant capacity were measured. Slc:ICR (ICR) mice were treated with cisplatin, G. lucidum, or both. The survival rate and physiological data were measured. Results: G. lucidum suppressed cisplatin-induced cytotoxicity and apoptosis in RAW264.7 cells. G. lucidum suppressed cisplatin-induced nephrotoxicity and gastrointestinal toxicity via its antioxidant effects in ICR mice. Conclusion: The suppressive mechanism of G. lucidum may be mediated via its antioxidant effects. These findings indicate its potential to reduce the side effects of cisplatin.