<?xml version='1.0' encoding='UTF-8'?><xml><records><record><source-app name="HighWire" version="7.x">Drupal-HighWire</source-app><ref-type name="Journal Article">17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">OTA, NATSUKI</style></author><author><style face="normal" font="default" size="100%">ENDO, SHOYA</style></author><author><style face="normal" font="default" size="100%">TATSUNAMI, RYOSUKE</style></author><author><style face="normal" font="default" size="100%">YAMAGUCHI, AOI</style></author><author><style face="normal" font="default" size="100%">WAKAME, KOJI</style></author><author><style face="normal" font="default" size="100%">NAKATA, AKIFUMI</style></author><author><style face="normal" font="default" size="100%">SATO, KEISUKE</style></author></authors><secondary-authors></secondary-authors></contributors><titles><title><style face="normal" font="default" size="100%">Effect of &lt;em&gt;Ganoderma lucidum&lt;/em&gt; on Cisplatin-induced Nephrotoxicity and Gastrointestinal Toxicity</style></title><secondary-title><style face="normal" font="default" size="100%">Anticancer Research</style></secondary-title></titles><dates><year><style  face="normal" font="default" size="100%">2024</style></year><pub-dates><date><style  face="normal" font="default" size="100%">2024-08-01 00:00:00</style></date></pub-dates></dates><pages><style  face="normal" font="default" size="100%">3605-3613</style></pages><doi><style  face="normal" font="default" size="100%">10.21873/anticanres.17183</style></doi><volume><style face="normal" font="default" size="100%">44</style></volume><issue><style face="normal" font="default" size="100%">8</style></issue><abstract><style  face="normal" font="default" size="100%">Background/Aim: Cancer remains a major global health challenge, with an estimated 10 million cancer-related deaths in 2020, hindering efforts to extend life expectancy. Cisplatin, an effective platinum-based chemotherapeutic agent used against various malignancies, has numerous side effects. Ganoderma lucidum is a traditional Chinese medicine with extensive historical use and proven biological activity. This study investigated the effects of G. lucidum on cisplatin-induced nephrotoxicity and gastrointestinal toxicity. Materials and Methods: RAW264.7 cells were treated with cisplatin, G. lucidum, or both. Cytotoxicity and antioxidant capacity were measured. Slc:ICR (ICR) mice were treated with cisplatin, G. lucidum, or both. The survival rate and physiological data were measured. Results: G. lucidum suppressed cisplatin-induced cytotoxicity and apoptosis in RAW264.7 cells. G. lucidum suppressed cisplatin-induced nephrotoxicity and gastrointestinal toxicity via its antioxidant effects in ICR mice. Conclusion: The suppressive mechanism of G. lucidum may be mediated via its antioxidant effects. These findings indicate its potential to reduce the side effects of cisplatin.</style></abstract></record></records></xml>