RT Journal Article
SR Electronic
T1 Collision Carcinoma of the Residual Cervical Esophagus 27 Years after Esophageal Cancer Surgery
JF Anticancer Research
JO Anticancer Res
FD International Institute of Anticancer Research
SP 505
OP 511
VO 27
IS 1B
A1 YOSHIHIKO NARITAKA
A1 KENJI OGAWA
A1 TAKESHI SHIMAKAWA
A1 YOSHIHISA WAGATSUMA
A1 NORIYUKI ISOHATA
A1 SHINIICHI ASAKA
A1 AKIRA MIYAKI
A1 SHUNICHI SHIOZAWA
A1 TAKAO KATSUBE
A1 KAZUHIKO YOSHIMATSU
A1 MOTOHIKO AIBA
A1 HIROKO IDE
YR 2007
UL http://ar.iiarjournals.org/content/27/1B/505.abstract
AB A case of collision carcinoma (squamous cell carcinoma and Barrett's adenocarcinoma) in the residual cervical esophagus of a 68-year-old woman at 27 years after subtotal esophagectomy for thoracic esophageal carcinoma is reported. The patient initially noticed cervical dysphagia in 2002, but did not seek treatment. In April 2004, the patient was referred to our department by a local physician with the diagnosis of carcinoma of the cervical esophagus. In September 2004, the patient underwent resection of the cervical esophagus and partial resection of the gastric tube combined with cervical lymph node dissection under a diagnosis of double cancer (i.e., metachronous cervical esophageal carcinoma and carcinoma of the gastric tube). Esophagogastric continuity was restored by transplantation of a free jejunal graft with vascular anastomosis. Pathological examination showed squamous cell carcinoma on the esophageal side of the esophagogastric anastomosis and columnar epithelium with a tongue-shaped extension across the anastomotic line that included Barrett's epithelium, as well as adenocarcinoma, on the gastric tube side. The squamous cell carcinoma and adenocarcinoma were contiguous, but there was a distinct border between them and no morphological transition. Immunohistochemical staining showed positivity for p53 in the squamous carcinoma cells, while it was negative in the adenocarcinoma cells. In contrast, HER2 (c-erb-2) was strongly positive in the adenocarcinoma cells, but negative in the squamous carcinoma. Based on these findings, it was concluded that two separate carcinomas had arisen at different sites and grown independently until they collided and merged to form a collision carcinoma. Copyright© 2007 International Institute of Anticancer Research (Dr. John G. Delinassios), All rights reserved