TY - JOUR T1 - Prognostic Significance of Metallothionein, p53 Protein and Ki-67 Antigen Expression in Laryngeal Cancer JF - Anticancer Research JO - Anticancer Res SP - 335 LP - 342 VL - 27 IS - 1A AU - WOJCIECH PASTUSZEWSKI AU - PIOTR DZIEGIEL AU - TOMASZ KRECICKI AU - MARZENA PODHORSKA-OKOLOW AU - URSZULA CIESIELSKA AU - ELZBIETA GORZYNSKA AU - MACIEJ ZABEL Y1 - 2007/01/01 UR - http://ar.iiarjournals.org/content/27/1A/335.abstract N2 - Background: This study aimed at the evaluation of the expression of metallothionein (MT) in laryngeal carcinoma and its correlation with the expression of Ki-67 antigen and p53 protein and selected clinical and pathological variables in view of their potential prognostic significance. Materials and Methods: Sixty-five laryngeal cancer patients were retrospectively analysed. Expression of MT, Ki-67 and p53 in tumour tissue samples were assessed by immunohistochemistry. Results: In laryngeal cancer a significantly augmented expression of MT, Ki-67 and p53 was noted, as compared to the control group (p<0.001) and a significantly increased expression of MT in low malignancy tumours (G1) as compared to the control group (p<0.001). The expression of Ki-67 antigen was positively correlated with the expression of p53 protein (r=0.477; p<0.05) and expression of either marker was positively correlated with malignancy grade (r=0.47, p<0.05; r=0.31, p<0.05; for Ki-67 and p53, respectively). Shortened survival was noted in patients with high expression of Ki-67 antigen and p53 protein. Conclusion: The intensity of MT expression was not related to prognosis in laryngeal cancer. Nevertheless, it may provide a significant index indicating the malignant transformation of benign lesions of laryngeal epithelium. ER -