RT Journal Article
SR Electronic
T1 Associations of Matrix Metalloproteinase-8 Genotypes to Renal Cell Carcinoma in Taiwan
JF Anticancer Research
JO Anticancer Res
FD International Institute of Anticancer Research
SP 1931
OP 1938
DO 10.21873/anticanres.16995
VO 44
IS 5
A1 LIAO, CHENG-HSI
A1 CHIEN, WEI-CHING
A1 CHANG, SHU-YU
A1 LIN, YU-HSIN
A1 WANG, YUN-CHI
A1 HUANG, WEN-CHIN
A1 MONG, MEI-CHIN
A1 YANG, YA-CHEN
A1 WU, WEN-TZU
A1 CHEN, JAW-CHYUN
A1 CHANG, CHAO-HSIANG
A1 TSAI, CHIA-WEN
A1 BAU, DA-TIAN
A1 CHANG, WEN-SHIN
YR 2024
UL http://ar.iiarjournals.org/content/44/5/1931.abstract
AB Background/Aim: Renal cell carcinoma (RCC) presents a formidable clinical challenge due to its aggressive behavior and limited therapeutic options. Matrix metalloproteinase-8 (MMP-8) has recently emerged as a potential biomarker and therapeutic target for various cancers. However, the genetic involvement of MMP-8 in RCC has remained largely obscure. This study aimed to elucidate the role of MMP-8 genotypes in RCC susceptibility. Materials and Methods: The polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) technique was employed to scrutinize the genotypes of MMP-8 C-799T (rs11225395), Val436Ala (rs34009635), and Lys460Thr (rs35866072) among 118 RCC patients and 590 controls. Furthermore, potential associations between MMP-8 genotypes and age, sex, smoking, alcohol consumption, hypertension, diabetes, and family history status in relation to RCC risk were assessed. Results: No significant disparities in the distribution of MMP-8 rs11225395, rs34009635, and rs35866072 genotypes were observed between the RCC case and control cohorts (p>0.05). Individuals with CT and TT genotypes at MMP-8 rs11225395 exhibited 0.86- and 0.80-fold RCC risks, respectively (OR=0.57-1.31 and 0.42-1.55, p=0.5585 and 0.6228, respectively). Intriguingly, hypertensive individuals carrying the MMP-8 rs11225395 CT or TT genotype demonstrated an elevated risk for RCC compared to those with wild-type CC genotype (p=0.0440). No interactions of MMP-8 genotypes with age, sex, smoking, alcohol consumption, or diabetes status were evident (all p>0.05). No significant association was discerned for MMP-8 rs34009635 or rs35866072 genotypes. Conclusion: MMP-8 genotypes appear to have a modest influence on individual susceptibility to RCC. Hypertensive patients with the CT or TT MMP-8 rs11225395 genotype may have an elevated risk of RCC.