PT  - JOURNAL ARTICLE
AU  - LIAO, CHENG-HSI
AU  - CHIEN, WEI-CHING
AU  - CHANG, SHU-YU
AU  - LIN, YU-HSIN
AU  - WANG, YUN-CHI
AU  - HUANG, WEN-CHIN
AU  - MONG, MEI-CHIN
AU  - YANG, YA-CHEN
AU  - WU, WEN-TZU
AU  - CHEN, JAW-CHYUN
AU  - CHANG, CHAO-HSIANG
AU  - TSAI, CHIA-WEN
AU  - BAU, DA-TIAN
AU  - CHANG, WEN-SHIN
TI  - Associations of Matrix Metalloproteinase-8 Genotypes to Renal Cell Carcinoma in Taiwan
AID  - 10.21873/anticanres.16995
DP  - 2024 May 01
TA  - Anticancer Research
PG  - 1931--1938
VI  - 44
IP  - 5
4099  - http://ar.iiarjournals.org/content/44/5/1931.short
4100  - http://ar.iiarjournals.org/content/44/5/1931.full
SO  - Anticancer Res2024 May 01; 44
AB  - Background/Aim: Renal cell carcinoma (RCC) presents a formidable clinical challenge due to its aggressive behavior and limited therapeutic options. Matrix metalloproteinase-8 (MMP-8) has recently emerged as a potential biomarker and therapeutic target for various cancers. However, the genetic involvement of MMP-8 in RCC has remained largely obscure. This study aimed to elucidate the role of MMP-8 genotypes in RCC susceptibility. Materials and Methods: The polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) technique was employed to scrutinize the genotypes of MMP-8 C-799T (rs11225395), Val436Ala (rs34009635), and Lys460Thr (rs35866072) among 118 RCC patients and 590 controls. Furthermore, potential associations between MMP-8 genotypes and age, sex, smoking, alcohol consumption, hypertension, diabetes, and family history status in relation to RCC risk were assessed. Results: No significant disparities in the distribution of MMP-8 rs11225395, rs34009635, and rs35866072 genotypes were observed between the RCC case and control cohorts (p>0.05). Individuals with CT and TT genotypes at MMP-8 rs11225395 exhibited 0.86- and 0.80-fold RCC risks, respectively (OR=0.57-1.31 and 0.42-1.55, p=0.5585 and 0.6228, respectively). Intriguingly, hypertensive individuals carrying the MMP-8 rs11225395 CT or TT genotype demonstrated an elevated risk for RCC compared to those with wild-type CC genotype (p=0.0440). No interactions of MMP-8 genotypes with age, sex, smoking, alcohol consumption, or diabetes status were evident (all p>0.05). No significant association was discerned for MMP-8 rs34009635 or rs35866072 genotypes. Conclusion: MMP-8 genotypes appear to have a modest influence on individual susceptibility to RCC. Hypertensive patients with the CT or TT MMP-8 rs11225395 genotype may have an elevated risk of RCC.