RT Journal Article
SR Electronic
T1 Proteomic Approaches for Serum Biomarker Discovery in Cancer
JF Anticancer Research
JO Anticancer Res
FD International Institute of Anticancer Research
SP 1247
OP 1255
VO 27
IS 3A
A1 MAURYA, PRIYANKA
A1 MELEADY, PAULA
A1 DOWLING, PAUL
A1 CLYNES, MARTIN
YR 2007
UL http://ar.iiarjournals.org/content/27/3A/1247.abstract
AB Monitoring the protein expression pattern in tumour cells by proteomics technologies offers opportunities to discover potentially new biomarkers for the early detection and diagnosis of cancer. Different proteomic tools such as 2D-PAGE, 2D-DIGE, SELDI-ToF-MS technology, protein arrays, ICAT, iTRAQ and MudPIT have been used for differential analysis of various biological samples, including cell lysates, cell secretome (conditioned medium), serum, plasma, tumour tissue and nipple aspirate fluid, to better understand the molecular basis of cancer pathogenesis and the validation and characterisation of disease-associated proteins. In recent years, there has been a large increase in cancer-related publications dealing with new biomarker discovery for cancer, therefore, in this review we have focused on the contribution of proteomics technologies in serum and conditioned medium-based oncology research particularly for lung, breast, melanoma and pancreatic cancer. Copyright© 2007 International Institute of Anticancer Research (Dr. John G. Delinassios), All rights reserved