RT Journal Article
SR Electronic
T1 Muscle–Invasive Bladder Cancer With Hydronephrosis Exhibits a High Frequency of Mutations in Fibroblast Growth Factor Receptor 3 Gene
JF Anticancer Research
JO Anticancer Res
FD International Institute of Anticancer Research
SP 1947
OP 1954
DO 10.21873/anticanres.16997
VO 44
IS 5
A1 KOBATAKE, KOHEI
A1 IKEDA, KENICHIRO
A1 KOHADA, YUKI
A1 TASAKA, RYO
A1 TAKEMOTO, KENSHIRO
A1 FUKUSHIMA, TAKAFUMI
A1 MIYAMOTO, SHUNSUKE
A1 SEKINO, YOHEI
A1 KITANO, HIROYUKI
A1 GOTO, KEISUKE
A1 HIEDA, KEISUKE
A1 GORIKI, AKIHIRO
A1 HAYASHI, TETSUTARO
A1 HINATA, NOBUYUKI
YR 2024
UL http://ar.iiarjournals.org/content/44/5/1947.abstract
AB Background/Aim: Recent studies have reported conflicting findings regarding the significance of hydronephrosis (HN) in muscle-invasive bladder cancer (MIBC). The molecular characteristics of MIBC with HN are unclear, therefore, we aimed to address the gaps in previous research and elucidate HN’s molecular significance in patients with MIBC. Materials and Methods: Clinical, genetic, and imaging information on bladder cancer patients enrolled in The Cancer Genome Atlas were obtained from public databases to analyze the association between the presence of hydronephrosis and genetic alterations and molecular subtyping. A total of 108 patients who underwent total cystectomy for MIBC at the Hiroshima University Hospital were enrolled in the study to verify the association between HN and renal function with patient prognosis. Results: We observed a statistically significant difference in the distribution of molecular subtypes (p=0.0146). The proportion of patients with the luminal papillary subtype was approximately twice as high in patients with HN (48.8%) than in those without HN (25.0%). The mutation frequency of fibroblast growth factor receptor (FGFR) 3 was approximately three-fold higher in patients with HN (20.9%) than in those without HN (7.1%). Multivariate analysis, which considered HN and estimated glomerular filtration rate as confounding factors in our MIBC cohort, revealed that reduced renal function, but not HN, was an independent predictor for overall survival. Conclusion: MIBC presenting HN exhibits a high frequency of mutations in the FGFR3 gene. In addition, not HN itself, but reduced renal function due to HN may worsen the prognosis for MIBC.