RT Journal Article
SR Electronic
T1 Locoregional IL-2 Therapy in the Treatment of Colon Cancer. Cell-induced Lesions of a Murine Model
JF Anticancer Research
JO Anticancer Res
FD International Institute of Anticancer Research
SP 985
OP 989
VO 27
IS 2
A1 CAPORALE, A.
A1 BRESCIA, A.
A1 GALATI, G.
A1 CASTELLI, M.
A1 SAPUTO, S.
A1 TERRENATO, I.
A1 CUCINA, A.
A1 LIVERANI, A.
A1 GASPARRINI, M.
A1 CIARDI, A.
A1 SCARPINI, M.
A1 COSENZA, U.M.
YR 2007
UL http://ar.iiarjournals.org/content/27/2/985.abstract
AB Background: Local therapy with IL-2 may be very effective in the treatment of different forms of cancer. The aim of this study was to determine the effectiveness of IL-2 locoregional application in the treatment of colon cancer. Materials and Methods: Twenty eight syngenic BDIX rats were utilized in this study. The rats were divided into two groups of fourteen animals: group T (treatment) and group C (control). All rats of both groups were injected, under the splenic capsule, with T 107 DHD/K12/ TRb neoplastic cells. Then, within and around the site of the previous inoculation, the T group was injected with 1 ml of glucosate solutions + 0.1% albumin (BSA) containing 2.5×106 IU of IL-2 (Proleukin-Chiron), whereas the C group was injected with 1 ml of BSA alone. After three weeks, rats were sacrificed and the liver and spleen were removed. The following parameters were considered: volume and weight, neoplastic-non neoplastic tissue index of the spleen, mitotic index and vascular density of splenic and hepatic lesions. Results: All the studied parameters showed statistically significant differences in treated and untreated animals. Conclusion: This study of a murine model demonstrated that IL-2 locoregional therapy may be effective in the treatment of colon cancer. Copyright© 2007 International Institute of Anticancer Research (Dr. John G. Delinassios), All rights reserved