TY - JOUR T1 - Effects of ACE I/D Polymorphism on Prostate Cancer Risk, Tumor Grade and Metastatis JF - Anticancer Research JO - Anticancer Res SP - 933 LP - 936 VL - 27 IS - 2 AU - BULENT YIGIT AU - NILÜFER BOZKURT AU - FEHMI NARTER AU - HULYA YILMAZ AU - ERGIN YUCEBAS AU - TURGAY ISBIR Y1 - 2007/03/01 UR - http://ar.iiarjournals.org/content/27/2/933.abstract N2 - The aim was to substantiate the putative significance of angiotensin-converting enzyme (ACE) (insertion/deletion) I/D polymorphism on prostate cancer risk, BTPSA-ATPSA (before treatment-after treatment prostate-specific antigen) levels and tumor development. Materials and Methods: 48 prostate cancer patients and 51 healthy volunteers were included. The ACE I/D genotypes were determined by PCR (polymerase chain reaction) and RFLP (restriction fragment length polymorphism) techniques. Results: The DD genotype may have detrimental and the II genotype may have protective effect on prostate cancer (p=0.03). The highest before treatment PSA (BTPSA) values were found in the patient group having the DD genotype (p=0.017). PSA-AT levels were higher in homozygous mutant DD than homozygous II and the decrease in PSA-AT level was found to be statistically significant in each genotype (p=0.000). Patients with the D allele showed a higher prevalence of late stage prostate carcinoma when compared to the patients with II genotype (p=0.022) and the detrimental effects of the D allele, both in lymph node metastases and distant metastasis were observed. Conclusion: The risk of prostate cancer development, the PSA level and tumor metastasis may be associated with genetic variation in the ACE I/D genotypes which may be used as an important biomarker for further studies. Copyright© 2007 International Institute of Anticancer Research (Dr. John G. Delinassios), All rights reserved ER -