RT Journal Article SR Electronic T1 Dermatofibrosarcoma Protuberans on Adult Toes: A Case Report and Review of the Literature JF Anticancer Research JO Anticancer Res FD International Institute of Anticancer Research SP 2105 OP 2111 DO 10.21873/anticanres.13323 VO 39 IS 4 A1 CAITLIN MADDEN A1 ADAM SPECTOR A1 SARWAT SIDDIQUI A1 GENE MIRKIN A1 JOON YIM A1 XINGPEI HAO YR 2019 UL http://ar.iiarjournals.org/content/39/4/2105.abstract AB Background: Dermatofibrosarcoma protuberans (DFSP) is an uncommon, low-grade, dermal soft-tissue neoplasm with high recurrence, but low metastatic potential. It mainly occurs on the trunk, proximal extremity, head and neck, but rarely on the toes. Herein we report a case of DFSP on the right hallux. Case Report: A 39-year-old male presented with a mass in the right great toe of 3.5 years. After surgical excision, histopathological evaluation of the mass showed elongated monomorphic spindle cells arranged in a storiform pattern. The tumor cells infiltrated into adjacent adipose tissue in a honeycomb formation. Immunostaining for CD34 showed diffuse and strong cytoplasmic expression in neoplastic cells, whereas that for alpha smooth muscle actin, factor XIIIa, S-100 and melan-A were negative. The tumor was diagnosed as DFSP. We further reviewed the literature of DFSP on the toes with the aim to reveal, for the first time as far as we are aware, its clinical presentations, histopathology, differential diagnosis and treatment options. Conclusion: DFSP on adult toes is a rare neoplasm characterized by monomorphic spindle cells arranged in storiform pattern, and can be treated with partial or total toe amputation, or wide local excision after primary excision, with excellent prognosis.