RT Journal Article
SR Electronic
T1 Clinical Impact of the Lymphocyte-to-Monocyte Ratio in Patients With Gastric Cancer who Received Curative Treatment
JF Anticancer Research
JO Anticancer Res
FD International Institute of Anticancer Research
SP 1567
OP 1574
DO 10.21873/anticanres.16954
VO 44
IS 4
A1 AOYAMA, TORU
A1 HASHIMOTO, ITARU
A1 MAEZAWA, YUKIO
A1 HARA, KENTARO
A1 TAMAGAWA, AYAKO
A1 CHO, HARUHIKO
A1 NUMATA, MASAKATSU
A1 MORITA, JUNYA
A1 TANABE, MIE
A1 KAWAHARA, SHINNOSUKE
A1 OSHIMA, TAKASHI
A1 SAITO, AYA
A1 YUKAWA, NORIO
A1 RINO, YASUSHI
YR 2024
UL http://ar.iiarjournals.org/content/44/4/1567.abstract
AB Background/Aim: The aim of the present study was to evaluate the clinical impact of the pretreatment lymphocyte-to-monocyte ratio (LMR) on both short- and long-term oncological outcomes in patients with resectable gastric cancer (GC). Patients and Methods: The patients were chosen based on our medical records from consecutive cases of curative resection for GC performed at Yokohama City University from 2005 to 2020. The LMR was calculated as the lymphocyte count divided by the monocyte count measured before surgery. Results: The three- and five-year overall survival (OS) rates were 63.1% and 57.4%, respectively, in the low-LMR subgroup and 86.4% and 77.5%, respectively, in the high-LMR subgroup. According to multivariate analysis, the LMR was an independent prognostic factor for OS [hazard ratio (HR)=1.926, 95% confidence interval (CI)=1.143-3.245, p=0.014]. In addition, the three- and five-year RFS rates were 54.4% and 50.7%, respectively, in the low-LMR subgroup and 84.0% and 76.0% in the high-LMR subgroup. According to multivariate analysis, the LMR was an independent prognostic factor for OS (HR=2.031, 95%CI=1.266-3.258, p=0.003). When comparing the sites of recurrence between the low-LMR and high-LMR groups, there were significant differences in hematologic recurrence, lymph node recurrence, and peritoneal recurrence. Conclusion: Preoperative LMR might be a promising tool for the treatment and management of GC.