PT  - JOURNAL ARTICLE
AU  - CAMILLO PORTA
AU  - LUCIA BONOMI
AU  - BEATRICE LILLAZ
AU  - CHIARA PAGLINO
AU  - BIANCA ROVATI
AU  - ILARIA IMARISIO
AU  - PATRIZIA MORBINI
AU  - CHIARA VILLA
AU  - MARCO DANOVA
AU  - MARIO MENSI
AU  - BRUNO ROVERETO
TI  - Renal Cell Carcinoma-induced Immunosuppression: An Immunophenotypic Study of Lymphocyte Subpopulations and Circulating Dendritic Cells
DP  - 2007 Jan 01
TA  - Anticancer Research
PG  - 165--173
VI  - 27
IP  - 1A
4099  - http://ar.iiarjournals.org/content/27/1A/165.short
4100  - http://ar.iiarjournals.org/content/27/1A/165.full
SO  - Anticancer Res2007 Jan 01; 27
AB  - Background: Renal cell carcinoma (RCC)-induced immune dysfunction in patients at first diagnosis was investigated. Patients and Methods: The main circulating lymphocyte subsets, the total number of circulating and intratumor dendritic cells and the titers of circulating VEGF were quantified in 47 RCC patients, using flow cytometric, immunohistochemical and ELISA assays. Results: Despite a significant activation of CD3/HLA-DR+ lymphocytes and of the CD56+ NK subset, RCC patients presented a marked immunosuppression of CD4/CD45RA naïve T-cells, CD4/CD45RO memory T-cells, CD16+ NK-cells, and total circulating dendritic cells, as well as a significant increase of lymphocytes co-expressing the CD4 and CD8 antigens. Finally, CD16+/CD56+ NK and DCs were poorly represented in tumor specimens. Conclusion: The complex immunological dysfunctions demonstrated involve different levels of immunocompetence and indicate a pattern of major disturbance of the immune system.