RT Journal Article SR Electronic T1 Induction of CD3+ and FoxP3+ T Cells in Left-sided Colorectal Tumors After UFT/LV Chemotherapy JF Anticancer Research JO Anticancer Res FD International Institute of Anticancer Research SP 1997 OP 2005 DO 10.21873/anticanres.13310 VO 39 IS 4 A1 SOTARO SADAHIRO A1 TOSHIYUKI SUZUKI A1 AKIRA TANAKA A1 KAZUTAKE OKADA A1 GOTA SAITO A1 HIROSHI MIYAKITA A1 LIN FUNG CHAN A1 YUTARO KAMEI A1 HIROSHI KAJIWARA A1 HIDEKI NAGASE YR 2019 UL http://ar.iiarjournals.org/content/39/4/1997.abstract AB Background/Aim: Immune checkpoint inhibitors are mainly used for right-sided, microsatellite instability-high colorectal tumors. In this study, the effects of oral uracil–tegafur plus leucovorin (UFT/LV) chemotherapy on the gene expressions of four immunotherapy targets and the amounts of tumor-infiltrating lymphocytes (TILs) were investigated. Patients and Methods: Data of 260 patients with stage II or stage III colorectal cancer were analyzed. Gene expression and amount of TILs were evaluated using real-time reverse transcription polymerase chain reaction (CRT-PCR) assay and immunohistochemical staining, respectively. Results: Expression of CTLA4 and LAG3 in tumor tissues was significantly increased after UFT/LV chemotherapy, but only in left-sided tumors. The percentage of high-TIL, high-CD3 and high-FoxP3 patients in the UFT/LV group was significantly higher than that in the control group, only in left-sided tumors. Conclusion: The increase in TILs count, especially of CD3+ T cells and FoxP3+ regulatory T cells, after UFT/LV chemotherapy were specific to left-sided colorectal cancers.