TY - JOUR T1 - Breast Radiotherapy and Early Adverse Cardiac Effects. The Role of Serum Biomarkers and Strain Echocardiography JF - Anticancer Research JO - Anticancer Res SP - 1667 LP - 1673 DO - 10.21873/anticanres.13272 VL - 39 IS - 4 AU - ARETI GKANTAIFI AU - CHRISTODOULOS PAPADOPOULOS AU - DESPOINA SPYROPOULOU AU - MARIA TOUMPOURLEKA AU - GEORGE ILIADIS AU - DIMITRIOS KARDAMAKIS AU - MICHAIL NIKOLAOU AU - NIKOLAOS TSOUKALAS AU - GEORGE KYRGIAS AU - MARIA TOLIA Y1 - 2019/04/01 UR - http://ar.iiarjournals.org/content/39/4/1667.abstract N2 - Breast cancer radiotherapy has a clear benefit for both long-term survival and local recurrence rate. However, there is still much concern about the early radiation-induced heart toxicity. This article aimed to clarify the impact of certain cardiac biomarkers and strain echocardiographic imaging on the detection of early cardiac dysfunction. Several studies that reported changes in either echocardiographic and/or serum levels measurements after breast radiotherapy were searched. Despite the established role of cardiac biomarkers to predict late cardiotoxicity after radiotherapy, data concerning early cardiac damage are still lacking. Furthermore, although strain echocardiography represents a specific tool for the detection of cardiac morbidity in certain diseases, much interest concerns its role in the prediction of early heart failure after radiotherapy. Identification of new tools for the detection of early cardiotoxicity after breast radiotherapy may minimize the side-effects of therapeutic modalities in the clinical setting. ER -