PT  - JOURNAL ARTICLE
AU  - SAKAMOTO, SHINICHI
AU  - ANDO, KEISUKE
AU  - PAE, SANGJON
AU  - ZHAO, XUE
AU  - SAKAI, KAZUKO
AU  - SATO, KODAI
AU  - SAITO, SHINPEI
AU  - YAMADA, YASUTAKA
AU  - RII, JUNRYO
AU  - GOTO, YUSUKE
AU  - SAZUKA, TOMOKAZU
AU  - IMAMURA, YUSUKE
AU  - ANZAI, NAOHIKO
AU  - AKAKURA, KOICHIRO
AU  - NISHIO, KAZUTO
AU  - ICHIKAWA, TOMOHIKO
TI  - Copy Number Gain in Androgen Receptors Predicts the Poor Prognosis in Japanese Castration-resistant Prostate Cancer
AID  - 10.21873/anticanres.16853
DP  - 2024 Feb 01
TA  - Anticancer Research
PG  - 639--647
VI  - 44
IP  - 2
4099  - http://ar.iiarjournals.org/content/44/2/639.short
4100  - http://ar.iiarjournals.org/content/44/2/639.full
SO  - Anticancer Res2024 Feb 01; 44
AB  - Background/Aim: The prognostic significance of androgen receptor amplification (AR amp) in cell-free DNA (cfDNA) was studied in Japanese patients with castration-resistant prostate cancer (CRPC). Patients and Methods: A total of 120 serum samples were obtained from 38 patients with CRPC. Serum cfDNA was purified and the AR copy number was determined. Factors associated with progression-free survival (PFS) and overall survival (OS) were statistically investigated. Results: The number of patients administered enzalutamide (Enza)/abiraterone (Abi)/docetaxel (DTX) was 33/25/11, respectively. The median PSA was 16.5 ng/ml. Thirty patients (79%) had bone metastases and three patients (7.9%) had lung metastases. The median follow-up was 655 days. The median initial AR copy number was 1.27 (1.10-11.50); an AR copy number of 1.27 or higher was defined as an AR-amp. Regarding PFS, the presence of AR-amp, Gleason score (GS), and ALP were significant factors in univariate analysis. In multivariate analysis, AR amplification was an independent prognostic factor (hazard ratio=7.7, p=0.0035). For OS, PSA and AR-amp were significant factors. In multivariate analysis, AR-amp (hazard ratio=4.65, p=0.0188) was the only independent prognostic factor. Conclusion: AR-amp was associated with high nadir PSA and low iPSA/PSA ratio. AR-amp was significantly associated with poor prognosis in Japanese patients with CRPC.