RT Journal Article
SR Electronic
T1 CRP-albumin-lymphocyte (CALLY) Index Is an Independent Prognostic Factor for the Esophageal Cancer Patients Who Received Curative Treatment
JF Anticancer Research
JO Anticancer Res
FD International Institute of Anticancer Research
SP 815
OP 822
DO 10.21873/anticanres.16873
VO 44
IS 2
A1 AOYAMA, TORU
A1 HASHIMOTO, ITARU
A1 MAEZAWA, YUKIO
A1 HARA, KENTARO
A1 KAZAMA, KEISUKE
A1 KOMORI, KEISUKE
A1 NUMATA, MASAKATSU
A1 TAMAGAWA, AYAKO
A1 FUKUDA, MOMOKO
A1 CHO, HARUHIKO
A1 MORITA, JUNYA
A1 YOSHIZAWA, SUZUE
A1 OTANI, KAZUKI
A1 KATO, AYA
A1 TANABE, MIE
A1 NAKAZONO, MASATO
A1 KAWAHARA, SHINNOSUKE
A1 OSHIMA, TAKASHI
A1 SAITO, AYA
A1 YUKAWA, NORIO
A1 RINO, YASUSHI
YR 2024
UL http://ar.iiarjournals.org/content/44/2/815.abstract
AB Background/Aim: Perioperative inflammation and the nutritional status affect both short- and long-term oncological outcomes in various malignancies. We clarified the clinical impacts of the CRP-albumin-lymphocyte (CALLY) index in patients with esophageal cancer who received curative treatment. Patients and Methods: The present study included 180 patients who underwent curative treatment for esophageal cancer between 2005 and 2020. The prognosis and clinicopathological parameters were compared between a high-fibrinogen group and a low-fibrinogen group. Results: The 3- and 5-year overall survival rates were 50.0% and 42.6%, respectively, in the CALLY index-low group, and 75.9% and 66.6% in the CALLY index-high group. The differences between the two groups were statistically significant (p<0.001). Univariate and multivariate analyses demonstrated that the CALLY index was an independent prognostic factor [hazard ratio=2.310, 95% confidence interval=1.416-3.767, p<0.001]. Similar results were observed in recurrence-free survival. When comparing the details of postoperative surgical complications, there was a significant difference in the incidence of anastomotic leakage. The incidence of anastomotic leakage was 40.2% in the CALLY index-low group, while it was 27.5% in the CALLY index-high group (p=0.030). Conclusion: The pretreatment CALLY index is one of the independent prognostic factors for esophageal cancer. The CALLY index might become a promising biomarker for the treatment and management of esophageal cancer.