PT  - JOURNAL ARTICLE
AU  - AOYAMA, TORU
AU  - HASHIMOTO, ITARU
AU  - MAEZAWA, YUKIO
AU  - HARA, KENTARO
AU  - KAZAMA, KEISUKE
AU  - KOMORI, KEISUKE
AU  - NUMATA, MASAKATSU
AU  - TAMAGAWA, AYAKO
AU  - FUKUDA, MOMOKO
AU  - CHO, HARUHIKO
AU  - MORITA, JUNYA
AU  - YOSHIZAWA, SUZUE
AU  - OTANI, KAZUKI
AU  - KATO, AYA
AU  - TANABE, MIE
AU  - NAKAZONO, MASATO
AU  - KAWAHARA, SHINNOSUKE
AU  - OSHIMA, TAKASHI
AU  - SAITO, AYA
AU  - YUKAWA, NORIO
AU  - RINO, YASUSHI
TI  - CRP-albumin-lymphocyte (CALLY) Index Is an Independent Prognostic Factor for the Esophageal Cancer Patients Who Received Curative Treatment
AID  - 10.21873/anticanres.16873
DP  - 2024 Feb 01
TA  - Anticancer Research
PG  - 815--822
VI  - 44
IP  - 2
4099  - http://ar.iiarjournals.org/content/44/2/815.short
4100  - http://ar.iiarjournals.org/content/44/2/815.full
SO  - Anticancer Res2024 Feb 01; 44
AB  - Background/Aim: Perioperative inflammation and the nutritional status affect both short- and long-term oncological outcomes in various malignancies. We clarified the clinical impacts of the CRP-albumin-lymphocyte (CALLY) index in patients with esophageal cancer who received curative treatment. Patients and Methods: The present study included 180 patients who underwent curative treatment for esophageal cancer between 2005 and 2020. The prognosis and clinicopathological parameters were compared between a high-fibrinogen group and a low-fibrinogen group. Results: The 3- and 5-year overall survival rates were 50.0% and 42.6%, respectively, in the CALLY index-low group, and 75.9% and 66.6% in the CALLY index-high group. The differences between the two groups were statistically significant (p<0.001). Univariate and multivariate analyses demonstrated that the CALLY index was an independent prognostic factor [hazard ratio=2.310, 95% confidence interval=1.416-3.767, p<0.001]. Similar results were observed in recurrence-free survival. When comparing the details of postoperative surgical complications, there was a significant difference in the incidence of anastomotic leakage. The incidence of anastomotic leakage was 40.2% in the CALLY index-low group, while it was 27.5% in the CALLY index-high group (p=0.030). Conclusion: The pretreatment CALLY index is one of the independent prognostic factors for esophageal cancer. The CALLY index might become a promising biomarker for the treatment and management of esophageal cancer.