RT Journal Article
SR Electronic
T1 Effect of Abdominal Aortic Calcification on Recurrence Following Initial Hepatectomy for Colorectal Liver Metastases
JF Anticancer Research
JO Anticancer Res
FD International Institute of Anticancer Research
SP 649
OP 658
DO 10.21873/anticanres.16854
VO 44
IS 2
A1 IMAOKA, KOUKI
A1 OHIRA, MASAHIRO
A1 SHIMOMURA, MANABU
A1 HATTORI, MINORU
A1 BEKKI, TOMOAKI
A1 SATO, KOKI
A1 IMAOKA, YUKI
A1 AKABANE, SHINTARO
A1 NAKANO, RYOSUKE
A1 YANO, TAKUYA
A1 SAKAI, HIROSHI
A1 HIRATA, FUMIHIRO
A1 KURODA, SHINTARO
A1 TAHARA, HIROYUKI
A1 IDE, KENTARO
A1 ISHIYAMA, KOHEI
A1 KOBAYASHI, TSUYOSHI
A1 TANAKA, YUKA
A1 OHDAN, HIDEKI
YR 2024
UL http://ar.iiarjournals.org/content/44/2/649.abstract
AB Background/Aim: The aim of the study was to analyze the association between abdominal aortic calcification (AAC) and patient prognosis following resection of colorectal liver metastases (CRLM). AAC potentially reflects intrahepatic immunity and is involved in tumor development and progression. However, the clinical effects of AAC on colorectal cancer (CRC) prognosis after curative-intent liver resection for CRLM remain unclear. Patients and Methods: We evaluated the effect of AAC on the clinical prognosis and metastatic patterns in 99 patients who underwent hepatectomy for CRLM between 2010 and 2019. Results: The high-AAC group had significantly worse overall survival (OS) and remnant liver recurrence rate (RR) after propensity score matching to adjust for differences in baseline characteristics of patients and tumors. In multivariate Cox regression analyses, high AAC volume was an independent risk factor for poor OS and liver RR, but not poor lung RR. The expression of tumor necrosis factor-related apoptosis-inducing ligand, known as an anti-tumor marker, in liver natural killer (NK) cells was lower in the high-AAC group than in the low-AAC group. Conclusion: High AAC volume showed a strong relationship with remnant liver RR after curative resection of CRLM. High AAC volume may be responsible for the suppression of anti-tumor activity of liver NK cells, which results in an increased risk of liver recurrence and poor prognosis.