PT  - JOURNAL ARTICLE
AU  - BATZIOS, S.
AU  - MICHALOPOULOS, A.
AU  - KAKLAMANIS, L.
AU  - STATHOPOULOS, J.
AU  - CHRISTOPOULOU, M.
AU  - KOUTANTOS, J.
AU  - STATHOPOULOS, G.P.
TI  - Angiosarcoma of the Heart: Case Report and Review of the Literature
DP  - 2006 Nov 01
TA  - Anticancer Research
PG  - 4837--4842
VI  - 26
IP  - 6C
4099  - http://ar.iiarjournals.org/content/26/6C/4837.short
4100  - http://ar.iiarjournals.org/content/26/6C/4837.full
SO  - Anticancer Res2006 Nov 01; 26
AB  - Background: Primary angiosarcoma of the heart is an extremely rare malignant disease. Patients and Methods: A 32-year-old female with primary angiosarcoma of the heart at an advanced stage with lung and bone metastases is presented. The tumor showed extensive expression of c-erb-B2 and a moderate expression of c-kit. Chemotherapy (cisplatin, epirubicin and ifosfamide) was administered. Herceptin as well as glivec were added to the above combination. Results: There was a good partial response and the lung deposits almost disappeared. The duration of response was 6 months. Conclusion: This case of angiosarcoma of the heart is presented because of the extreme rarity of this disease, and its responsiveness to chemotherapy in combination with imatinib and herceptin. Copyright© 2006 International Institute of Anticancer Research (Dr. John G. Delinassios), All rights reserved