RT Journal Article
SR Electronic
T1 Lymphocyte to Monocyte Ratio Is an Independent Prognostic Factor in Patients With Esophageal Cancer Who Receive Curative Treatment
JF Anticancer Research
JO Anticancer Res
FD International Institute of Anticancer Research
SP 339
OP 346
DO 10.21873/anticanres.16817
VO 44
IS 1
A1 AOYAMA, TORU
A1 KATO, AYA
A1 MAEZAWA, YUKIO
A1 HASHIMOTO, ITARU
A1 HARA, KENTARO
A1 KOMORI, KEISUKE
A1 KAWAHARA, SHINNOSUKE
A1 NUMATA, MASAKATSU
A1 KAZAMA, KEISUKE
A1 SAWAZAKI, SHO
A1 KAMIYA, NATSUMI
A1 YOSHIZAWA, SUZUE
A1 OTANI, KAZUKI
A1 TAMAGAWA, AYAKO
A1 CHO, HARUHIKO
A1 TAMAGAWA, HIROSHI
A1 OSHIMA, TAKASHI
A1 YUKAWA, NORIO
A1 SAITO, AYA
A1 RINO, YASUSHI
YR 2024
UL http://ar.iiarjournals.org/content/44/1/339.abstract
AB Background/Aim: This study evaluated the clinical impact of the lymphocyte-to-monocyte ratio (LMR) in patients with esophageal cancer who received curative treatment and perioperative adjuvant treatment. The association between LMR and the clinicopathological characteristics of patients with esophageal cancer was also investigated. Patients and Methods: This study included 181 patients who underwent curative treatment for esophageal cancer between 2005 and 2020. The prognosis and clinicopathological parameters of patients with high and low LMR statuses were analyzed. Results: The OS rates at 3 and 5 years after surgery were significantly lower (40.6% and 33.8%, respectively) in the low-LMR group than in the high-LMR group (67.1% and 58.4%, respectively). The pretreatment LMR was selected as an independent prognostic factor in the multivariate analysis model [hazard ratio (HR)=2.606; 95%CI=1.504-4.516, p<0.001]. Similar results were observed for RFS. Furthermore, LMR was associated with the occurrence of postoperative surgical complications and hematological recurrence. The incidence of anastomotic leakage was 63.3% in the low-LMR group and 27.2% in the high-LMR group (p<0.001). Moreover, the hematologic recurrence rate in the low-LMR group was significantly higher than that in the high-LMR group (46.7% vs. 23.8%, p=0.011). Conclusion: The LMR may be a promising prognostic and predictive factor for esophageal cancer, and may be used to select optimal treatment strategies in the future.