TY - JOUR T1 - Ovarian Cancer Screening JF - Anticancer Research JO - Anticancer Res SP - 4793 LP - 4801 VL - 26 IS - 6C AU - M. KYRGIOU AU - I. TSOUMPOU AU - P. MARTIN-HIRSCH AU - M. ARBYN AU - W. PRENDIVILLE AU - G. KOLIOPOULOS AU - N. DALKALITSIS AU - P. STAMATOPOULOS AU - E. PARASKEVAIDIS Y1 - 2006/11/01 UR - http://ar.iiarjournals.org/content/26/6C/4793.abstract N2 - Purpose: This review presents the current knowledge on ovarian cancer screening (OCS) together with a cumulative evaluation of the efficacy across diverse screening approaches based on up-to-date results. Materials and Methods: An electronic literature search was conducted targeting reports on the effectiveness of the various screening strategies. Results: Twenty-two prospective studies, 18 cohorts and 4 randomised control trials (RCTs) were retrieved. Where possible, sensitivity, specificity and predictive values, as well as the number needed to treat for each cancer (NNT) and each stage I disease [NNT (I)] detected are reported. Conclusion: The multimodal approach that incorporates CA125 as a primary and ultrasound as a secondary test appears to be superior to other strategies. However, the conclusive end-point that would provide the acceptable level of evidence for the introduction of screening should be a reduction in mortality. Up-to-date, there is no such evidence to justify this. Copyright© 2006 International Institute of Anticancer Research (Dr. John G. Delinassios), All rights reserved ER -