PT  - JOURNAL ARTICLE
AU  - KENJI HIBI
AU  - AKIMASA NAKAO
TI  - Highly-methylated Colorectal Cancers Show Poorly-differentiated Phenotype
DP  - 2006 Nov 01
TA  - Anticancer Research
PG  - 4263--4266
VI  - 26
IP  - 6B
4099  - http://ar.iiarjournals.org/content/26/6B/4263.short
4100  - http://ar.iiarjournals.org/content/26/6B/4263.full
SO  - Anticancer Res2006 Nov 01; 26
AB  - The combined methylation status of p16, p14, HLTF, SOCS-1, CDH13, RUNX3 and CHFR was examined in 58 resected primary colorectal cancers using methylation-specific PCR, and the methylation status was correlated with the clinicopathological features of the affected patients. A significant difference in histology (p=0.0041) was observed when the number of methylated genes of poorly-differentiated colorectal cancers was compared to that of other differentiated ones. Poorly-differentiated colorectal cancers preferentially exhibited gene methylation. Copyright© 2006 International Institute of Anticancer Research (Dr. John G. Delinassios), All rights reserved