RT Journal Article SR Electronic T1 The Emerging Role of Calcium-activated Chloride Channel Regulator 1 in Cancer JF Anticancer Research JO Anticancer Res FD International Institute of Anticancer Research SP 1661 OP 1666 DO 10.21873/anticanres.13271 VO 39 IS 4 A1 DINGYUAN HU A1 DANIEL ANSARI A1 MONIKA BAUDEN A1 QIMIN ZHOU A1 ROLAND ANDERSSON YR 2019 UL http://ar.iiarjournals.org/content/39/4/1661.abstract AB Calcium-activated chloride channel regulator 1 (CLCA1) belongs to a group of secreted self-cleaving proteins, which activate calcium-dependent chloride channels. CLCA1 has been shown to participate in the pathogenesis of inflammatory airway diseases such as asthma. Recently, additional functions of CLCA1 have been unveiled, including its metalloprotease property and involvement in mucus homeostasis and immune modulation. Emerging evidence suggests that CLCA1 may also be involved in the pathophysiology of colorectal, pancreatic and ovarian cancer. There is growing interest in utilizing CLCA1 as a diagnostic, prognostic and predictive biomarker, as well as a potential therapeutic target. In this review, the functional role of CLCA1, with a particular focus on cancer, is described.