RT Journal Article
SR Electronic
T1 Preoperative PI-RADS v2.1 Scoring System Improves Risk Classification in Patients Undergoing Radical Prostatectomy
JF Anticancer Research
JO Anticancer Res
FD International Institute of Anticancer Research
SP 5705
OP 5712
DO 10.21873/anticanres.16776
VO 43
IS 12
A1 FUKUI, YUDAI
A1 YAMADA, YASUTAKA
A1 SAKAMOTO, SHINICHI
A1 HORIKOSHI, TAKURO
A1 ZHAO, XUE
A1 SATO, KODAI
A1 NANBA, SAKIE
A1 KUBOTA, YOSHIHIRO
A1 KANESAKA, MANATO
A1 FUJIMOTO, AYUMI
A1 SHIBATA, HIROKI
A1 GOTO, YUSUKE
A1 SAZUKA, TOMOKAZU
A1 IMAMURA, YUSUKE
A1 UNO, TAKASHI
A1 ICHIKAWA, TOMOHIKO
YR 2023
UL http://ar.iiarjournals.org/content/43/12/5705.abstract
AB Background/Aim: The purpose of this study was to examine the prognostic value of Prostate imaging-reporting and data system (PI-RADS) v2.1 scoring system in patients who underwent radical prostatectomy (RP). Patients and Methods: Clinical data of 294 patients who received RP between 2006 and 2018 were reviewed and multiple parameters including PI-RADS v2.1 score were employed to identify predictive factors for biochemical recurrence (BCR). Tumor volume was calculated from prostatectomy specimens. Results: Median age at operation and initial PSA level were 67 years old and 7.68 ng/ml, respectively. 44.9 and 24.8% of patients were diagnosed with PI-RADS score 4 and 5 prior to biopsies, respectively. BCR was observed in 17% of patients and median observation period was 63.43 months. After multivariate analysis, PI-RADS v2.1 score 5 [hazard ratio (HR)=2.24, p=0.0124] was an independent predictive factor of BCR in addition to clinical T stage (≥2c) (HR=2.32, p=0.0093) and biopsy Gleason score (≥8) (HR=2.81, p=0.0007). Furthermore, PI-RADS score 5 significantly stratified the prognosis in D’Amico intermediate- and high-risk groups (p=0.0174 and p=0.0013, respectively). We established novel risk classifications including PI-RADS v2.1 score and found that prognostic capabilities were improved as compared to the D’Amico classification. Conclusion: The PI-RADS v2.1 score exhibited significant prognostic value in patients with localized prostate cancer following RP. Risk classifications based on PI-RADS v2.1 score might provide better ability for predicting oncological outcomes as compared to the D’Amico classification system.